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【结 构 式】 
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【分子编号】39801 【品名】benzhydryl (6R,7R)-3-(hydroxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 【CA登记号】 |
【 分 子 式 】C27H24N2O5S2 【 分 子 量 】520.63004 【元素组成】C 62.29% H 4.65% N 5.38% O 15.37% S 12.32% |
合成路线1
该中间体在本合成路线中的序号：(I)Compound can be prepared by several related ways: 1) The reaction of diphenylmethyl (6R,7R)-3-hydroxymethyl-7-(2-thienylacetamido)ceph-3-em-4-carboxylate (I) with trichloroacetyl isocyanate (A) in anhydrous acetone gives the corresponding N-trichloroacetylcarbamate (II), which by reaction with PCl5 and pyridine in CH2Cl2 and then with p-toluenesulfonic acid affords diphenylmethyl 7-amino-3-carbamoyloxymethylceph-3-em-4-carboxylate p-toluenesulfonic acid salt (III). The hydrolysis of (III) with trifluoroacetic acid in anisole yields the corresponding acid (IV), which is finally condensed with 2-(2-furyl)-2-methoxyiminoacetic acid (V) by means of PCl5 and N,N-dimethylacetamide in acetonitrile containing triethylamine. 2) The elimination of the protecting groups of compound (II) can also be performed stepwise with isolation of the intermediate p-toluenesulfonic salt (VI). 3) The deprotected compound (III) can also be treated first with NaHCO3 and then condensed with the acetic acid (V) by means of dicyclohexylcarbodiimide in CH2Cl2 to give the diphenvimethyl ester (VII), which is finally hydrolyzed with trifluoroacetic acid.
| 【1】 Loren, J.G.; Castañer, J.; Cefuroxime. Drugs Fut 1978, 3, 4, 266. |
| 【2】 Cook, M.C.; et al. (Glaxo Group Ltd.); 7-Hydrocarbonoxyiminoacetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids. US 3974153 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 39802 | 2,2,2-trichloroacetyl thiocyanate | C3Cl3NOS | 详情 | 详情 | |
| (I) | 39801 | benzhydryl (6R,7R)-3-(hydroxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C27H24N2O5S2 | 详情 | 详情 | |
| (II) | 39803 | benzhydryl (6R,7R)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[([[(2,2,2-trichloroacetyl)amino]carbonyl]oxy)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C30H24Cl3N3O7S2 | 详情 | 详情 | |
| (III) | 39804 | benzhydryl (6R,7R)-7-amino-3-[[(aminocarbonyl)oxy]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C22H21N3O5S | 详情 | 详情 | |
| (IV) | 39805 | (6R,7R)-7-amino-3-[[(aminocarbonyl)oxy]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C9H11N3O5S | 详情 | 详情 | |
| (V) | 39806 | 2-(2-furyl)-2-(methoxyimino)acetic acid | C7H7NO4 | 详情 | 详情 | |
| (VI) | 39807 | benzhydryl (6R,7R)-7-amino-8-oxo-3-[([[(2,2,2-trichloroacetyl)amino]carbonyl]oxy)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C24H20Cl3N3O6S | 详情 | 详情 | |
| (VII) | 39808 | benzhydryl (6R,7R)-3-[[(aminocarbonyl)oxy]methyl]-7-[[2-(2-furyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C29H26N4O8S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)Acylation of 7-aminocephalosporanic acid (I) with 2-thienyleacetyl chloride (II) in the presence of NaOH led to amide (III). The carboxylate group of (III) was then protected as the corresponding benzhydryl ester (IV) upon treatment with diphenyldiazomethane. Mitsunobu coupling of the hydroxymethyl cephem (IV) with triclosan (V), with partial double-bond isomerization, gave rise to a mixture of the desired delta-3 ether (VI) and its delta-2 isomer (VII), which were separated by repeated column chromatography. Isomerization was minimized by conducting the reaction at -20 C. Finally, removal of the benzhydryl ester group of (VI) was accomplished by treatment with trifluoroacetic acid in the presence of anisole.
| 【1】 Li, Q.; et al.; NB2001, a novel antibacterial agent with broad-specrum activity and enhanced potency against beta-lactamase-producing strains. Antimicrob Agents Chemother 2002, 46, 5, 1262. |
| 【2】 Lobl, T.J.; Chan, M.F.; Li, Q.; Doppalapudi, V.R.; Hixon, M.S.; Castillo, R. (NewBiotics, Inc.); Improved beta-lactam antibiotics. WO 0183492 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22747 | (6R,7R)-3-[(acetoxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C10H12N2O5S | 详情 | 详情 | |
| (II) | 15673 | 2-(2-thienyl)acetyl chloride; 2-Thiopheneacetyl chloride | 39098-97-0 | C6H5ClOS | 详情 | 详情 |
| (III) | 55051 | (6R,7R)-3-(hydroxymethyl)-8-oxo-7-{[2-(2-thienyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C14H14N2O5S2 | 详情 | 详情 | |
| (IV) | 39801 | benzhydryl (6R,7R)-3-(hydroxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C27H24N2O5S2 | 详情 | 详情 | |
| (V) | 55052 | 2,4,4'-Trichloro-2'-hydroxydiphenyl ether; Triclosan | 3380-34-5 | C12H7Cl3O2 | 详情 | 详情 |
| (VI) | 55053 | benzhydryl (6R,7R)-3-{[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]methyl}-8-oxo-7-{[2-(2-thienyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C39H29Cl3N2O6S2 | 详情 | 详情 | |
| (VII) | 55054 | benzhydryl (6R,7R)-3-{[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]methyl}-8-oxo-7-{[2-(2-thienyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate | C39H29Cl3N2O6S2 | 详情 | 详情 |