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【结 构 式】

【分子编号】39798

【品名】4-chloro-N-(4-hydroxyphenethyl)benzamide

【CA登记号】41859-57-8

【 分 子 式 】C15H14ClNO2

【 分 子 量 】275.7344

【元素组成】C 65.34% H 5.12% Cl 12.86% N 5.08% O 11.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The benzoylation of tyramine (2-(p-hydroxyphenyl)ethylamine) (I) with 4-chlorobenzoyl chloride (II) in pyridine gives 4-(4-chlorobenzoylaminoethyl)phenol (III), which by condensation with ethyl alpha-bromoisobutyrate (IV) by means of K2CO3 in refluxing butanone affords ethyl alpha-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyrate (V). Finally, this compound is hydrolyzed with KOH in dioxane - water.

1 Castañer, J.; Thorpe. P.; Bezafibrate. Drugs Fut 1978, 3, 4, 258.
2 Witte, E.C.; et al. (Boehringer Ingelheim GmbH); Phenoxyalkylcarbosaurederivate und Verfahren zur Herstellung derselben. DE 2149070; ZA 7206638 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10295 p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride 122-01-0 C7H4Cl2O 详情 详情
(II) 19988 4-(2-Aminoethyl)phenol; Tyramine 51-67-2 C8H11NO 详情 详情
(III) 39798 4-chloro-N-(4-hydroxyphenethyl)benzamide 41859-57-8 C15H14ClNO2 详情 详情
(IV) 39799 ethyl 2-bromo-2-methylpropanoate 600-00-0 C6H11BrO2 详情 详情
(V) 39800 ethyl 2-(4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy)-2-methylpropanoate C21H24ClNO4 详情 详情
Extended Information