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【结 构 式】 
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【分子编号】39780 【品名】 【CA登记号】 |
【 分 子 式 】C121H207N2O21P 【 分 子 量 】2056.949222 【元素组成】C 70.65% H 10.14% N 1.36% O 16.33% P 1.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVII)Coupling of intermediates (V) and (XIII) in the presence of silver triflate gave disaccharide (XIV). The trichloroethyl-based protecting groups of (XIV) were then removed with zinc dust in acetic acid to yield (XV). The glucosamine nitrogen of (XV) was selectively acylated with acid (XVI) to produce amide (XVII). The remaining protecting groups of (XVII) were finally removed by means of a two-phase catalytic hydrogenation employing palladium and platinum catalysts, yielding the title compound.
| 【1】 Sowell, C.G.; Weber, P.A.; Elliott, G.T. (Corixa Corp.); Phosphoglycolipid and methods for its use. WO 0011010 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 39768 | (1R)-1-[2-[((2R,3R,4R,5R,6R)-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-4-[[(2,2,2-trichloroethoxy)carbonyl]oxy]tetrahydro-2H-pyran-3-yl)amino]-2-oxoethyl]dodecyl palmitate | C46H76Cl3NO10 | 详情 | 详情 | |
| (XIII) | 39776 | (2R,3R,4R,5S,6R)-2-chloro-5-[(diphenoxyphosphoryl)oxy]-3-[(ethoxycarbonyl)amino]-6-([[(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl]oxy]methyl)tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C54H82Cl4NO14P | 详情 | 详情 | |
| (XIV) | 39777 | C100H157Cl6N2O24P | 详情 | 详情 | ||
| (XV) | 39778 | C89H147N2O18P | 详情 | 详情 | ||
| (XVI) | 39779 | (3R)-3-(stearoyloxy)tetradecanoic acid | C32H62O4 | 详情 | 详情 | |
| (XVII) | 39780 | C121H207N2O21P | 详情 | 详情 |
Extended Information