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【结 构 式】 
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【分子编号】39765 【品名】(3R)-3-(palmitoyloxy)tetradecanoic acid 【CA登记号】 |
【 分 子 式 】C30H58O4 【 分 子 量 】482.78812 【元素组成】C 74.64% H 12.11% O 13.26% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Coupling of protected 2-aminoglucopyranoside (I) with (R)-3-(hexadecanoyloxy)tetradecanoic acid (II) using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide gave amide (III). After protection of the 3-hydroxyl group of (III) with 2,2,2-trichloroethyl chloroformate, acetonide hydrolysis with aqueous acetic acid provided intermediate (V).
| 【1】 Sowell, C.G.; Weber, P.A.; Elliott, G.T. (Corixa Corp.); Phosphoglycolipid and methods for its use. WO 0011010 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16046 | (4aR,6R,7R,8R,8aS)-7-amino-6-(benzyloxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-8-ol | C16H23NO5 | 详情 | 详情 | |
| (II) | 39765 | (3R)-3-(palmitoyloxy)tetradecanoic acid | C30H58O4 | 详情 | 详情 | |
| (III) | 39766 | (1R)-1-(2-[[(4aR,6R,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl]amino]-2-oxoethyl)dodecyl palmitate | C46H79NO8 | 详情 | 详情 | |
| (IV) | 39767 | (1R)-1-[2-[((4aR,6R,7R,8R,8aR)-6-(benzyloxy)-2,2-dimethyl-8-[[(2,2,2-trichloroethoxy)carbonyl]oxy]hexahydropyrano[3,2-d][1,3]dioxin-7-yl)amino]-2-oxoethyl]dodecyl palmitate | C49H80Cl3NO10 | 详情 | 详情 | |
| (V) | 39768 | (1R)-1-[2-[((2R,3R,4R,5R,6R)-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-4-[[(2,2,2-trichloroethoxy)carbonyl]oxy]tetrahydro-2H-pyran-3-yl)amino]-2-oxoethyl]dodecyl palmitate | C46H76Cl3NO10 | 详情 | 详情 |
Extended Information