8-(7,8,9,9a-tetrahydro-1H-phenalen-3-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one -Drug Synthesis Database

【结构式】

【分子编号】39764

【品名】8-(7,8,9,9a-tetrahydro-1H-phenalen-3-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

【CA登记号】

【分子式】C₂₆H₂₉N₃O

【分子量】399.53588

【元素组成】C 78.16% H 7.32% N 10.52% O 4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The nitrosation of hexahydrophenalenone oxime (I) by means of NaNO2 and H2SO4 produced the N-nitroimine (II). Condensation of this intermediate with 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (III) in acetonitrile in the presence of molecular sieves gave rise to enamine (IV), which was finally reduced to the title amine using NaBH3CN.

参考文献中间体

合成目标

【1】 Adam, G.; Monsma, F.; Wichmann, J.; Jenck, F.; Galley, G.; Cesura, A.; Rover, S. (F. Hoffmann-La Roche AG); 8-Substd.-1,3,8-triazaspiro[4.5]decan-4-on derivs.. EP 0856514; US 6071925 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39762	2,3,3a,4,5,6-hexahydro-1H-phenalen-1-one oxime		C₁₃H₁₅NO	详情	详情
(II)	39763			C₁₃H₁₄N₂O₂	详情	详情
(III)	18116	1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one	1021-25-6	C₁₃H₁₇N₃O	详情	详情
(IV)	39764	8-(7,8,9,9a-tetrahydro-1H-phenalen-3-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one		C₂₆H₂₉N₃O	详情	详情

Extended Information