• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】39687

【品名】6-bromohexyl 2-chloro-4-methoxyphenyl ether; 1-[(6-bromohexyl)oxy]-2-chloro-4-methoxybenzene

【CA登记号】

【 分 子 式 】C13H18BrClO2

【 分 子 量 】321.64142

【元素组成】C 48.55% H 5.64% Br 24.84% Cl 11.02% O 9.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of 2-chloro-4-methoxyphenol (I) with 1,6-dibromohexane (II) by means of K2CO3 in refluxing acetone to give 1-(2-chloro-4-methoxyphenoxy)-6-bromohexane (III), which is converted into the corresponding iodo derivative (IV) by treatment with NaI in refluxing acetone. Finally, (IV) is treated with the lithium salt of 3,5-heptanedione (V) in ether - DMF.

1 Collins, J.C.; Diana, G.D.; 3,4-Methylenedioxyphenoxy-alkyl diketones and keto-esters. DE 2435378 .
2 Diana, G.D.; et al.; Antiviral acticity of some beta-diketones. 2. Aryloxy alkyl diketones. In vitro activity aganist both RNA and DNA viruses. J Med Chem 1977, 20, 6, 757-761.
3 Hopkins, S.J.; Castaner, J.; Arildone. Drugs Fut 1978, 3, 1, 12.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 39686 2-chloro-4-methoxyphenol 18113-03-6 C7H7ClO2 详情 详情
(II) 24786 1,6-dibromohexane 629-03-8 C6H12Br2 详情 详情
(III) 39687 6-bromohexyl 2-chloro-4-methoxyphenyl ether; 1-[(6-bromohexyl)oxy]-2-chloro-4-methoxybenzene C13H18BrClO2 详情 详情
(IV) 39688 3-chloro-4-[(6-iodohexyl)oxy]phenyl methyl ether; 2-chloro-1-[(6-iodohexyl)oxy]-4-methoxybenzene C13H18ClIO2 详情 详情
(V) 39689 3,5-heptanedione 7424-54-6 C7H12O2 详情 详情
Extended Information