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【结 构 式】 
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【分子编号】39575 【品名】methyl 2-(3-bromo-4-methoxyphenyl)acetate 【CA登记号】 |
【 分 子 式 】C10H11BrO3 【 分 子 量 】259.09954 【元素组成】C 46.36% H 4.28% Br 30.84% O 18.53% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)The starting phenylacetic acid (II) is prepared by an Ullman condensation between tert-butyl-4-hydroxyphenylacetate (XVII) and methyl 3-bromo-4-methoxyphenylacetate (XVIII) catalysed by CuO, followed by treatment with p-toluenesulfonic acid in benzene. Compound (XVII) is prepared by esterification of 4-benzyloxyphenylacetic acid (XIX) to the corresponding tart butyl ester (XX), followed by hydrogenolysis with H2 over Pd/C. Compound (XVIII) is prepared by methylation of methyl 3-bromo-4-hydroxyphenylacetate (XXI) with dimethyl sulfate and K2CO3 in DMF.
| 【1】 Kondo, H.; et al.; US 2206407 . |
| 【2】 Tomita, M.; et al.; Synthesis of di-cepharanthine. Tetrahedron Lett 1967, 1201-06. |
| 【3】 Serradell, M.N.; Blancafort, P.; Mealy, N.; Castañer, J.; Cepharanthine. Drugs Fut 1979, 4, 7, 481. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 39555 | 2-[4-[2-methoxy-5-(2-methoxy-2-oxoethyl)phenoxy]phenyl]acetic acid | C18H18O6 | 详情 | 详情 | |
| (XVII) | 39573 | 4-hydroxybenzyl pivalate | C12H16O3 | 详情 | 详情 | |
| (XVIII) | 39575 | methyl 2-(3-bromo-4-methoxyphenyl)acetate | C10H11BrO3 | 详情 | 详情 | |
| (XIX) | 39571 | 2-[4-(benzyloxy)phenyl]acetic acid | 6547-53-1 | C15H14O3 | 详情 | 详情 |
| (XX) | 39572 | 4-(benzyloxy)benzyl pivalate | C19H22O3 | 详情 | 详情 | |
| (XXI) | 39574 | methyl 2-(3-bromo-4-hydroxyphenyl)acetate | C9H9BrO3 | 详情 | 详情 |
Extended Information