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【结 构 式】

【分子编号】39575

【品名】methyl 2-(3-bromo-4-methoxyphenyl)acetate

【CA登记号】

【 分 子 式 】C10H11BrO3

【 分 子 量 】259.09954

【元素组成】C 46.36% H 4.28% Br 30.84% O 18.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVIII)

The starting phenylacetic acid (II) is prepared by an Ullman condensation between tert-butyl-4-hydroxyphenylacetate (XVII) and methyl 3-bromo-4-methoxyphenylacetate (XVIII) catalysed by CuO, followed by treatment with p-toluenesulfonic acid in benzene. Compound (XVII) is prepared by esterification of 4-benzyloxyphenylacetic acid (XIX) to the corresponding tart butyl ester (XX), followed by hydrogenolysis with H2 over Pd/C. Compound (XVIII) is prepared by methylation of methyl 3-bromo-4-hydroxyphenylacetate (XXI) with dimethyl sulfate and K2CO3 in DMF.

1 Kondo, H.; et al.; US 2206407 .
2 Tomita, M.; et al.; Synthesis of di-cepharanthine. Tetrahedron Lett 1967, 1201-06.
3 Serradell, M.N.; Blancafort, P.; Mealy, N.; Castañer, J.; Cepharanthine. Drugs Fut 1979, 4, 7, 481.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 39555 2-[4-[2-methoxy-5-(2-methoxy-2-oxoethyl)phenoxy]phenyl]acetic acid C18H18O6 详情 详情
(XVII) 39573 4-hydroxybenzyl pivalate C12H16O3 详情 详情
(XVIII) 39575 methyl 2-(3-bromo-4-methoxyphenyl)acetate C10H11BrO3 详情 详情
(XIX) 39571 2-[4-(benzyloxy)phenyl]acetic acid 6547-53-1 C15H14O3 详情 详情
(XX) 39572 4-(benzyloxy)benzyl pivalate C19H22O3 详情 详情
(XXI) 39574 methyl 2-(3-bromo-4-hydroxyphenyl)acetate C9H9BrO3 详情 详情
Extended Information