【结 构 式】 |
【分子编号】39523 【品名】N-[(2S)-3-anilino-3-oxo-2-(propionylamino)propyl]-N-(benzyloxy)benzamide 【CA登记号】 |
【 分 子 式 】C26H27N3O4 【 分 子 量 】445.5182 【元素组成】C 70.1% H 6.11% N 9.43% O 14.36% |
合成路线1
该中间体在本合成路线中的序号:(L)-(VI)Ethyl 2,3-dibromopropionate (I) is condensed with N-tosyl-O-benzylhydroxylamine (A) by means of NaOEt in ethanol to give after a treatment with ammonia, propionic acid (II), which is detosylated by treatment with phenol and 36% HBr- yielding D,L-2-amino-3-(benzyloxyamino)propionic acid (III). The benzoylation of (III) with N-benzoyloxysuccinimide (B) by means of Triton B - in methanol affords D,L-2-benzoylamino-3-benzyloxyaminopropionic acid (IV), which is resolved into its optical isomers by treatment with aniline (C) and papain in 0.5M NaOH - 0.5M citric acid and L-cysteine hydrochloride; L-2-benzoylamino-3-benzyloxyaminopropionanilide (L)-(V) was isolated. The benzoylation of (L)-(V) with benzoyl chloride (D) in pyridine affords L-2-benzoylamino-3-(N-benzoyl-N-benzyloxyamino)propionanilide (L)-(VI), which is debenzylated by hydrogenation with H2 over Pd/C in methanol giving L-2-benzoylamino-3-(N-benzoyl-N-hydroxyamino)propionanilide (L)-(VII). The protecting groups of (L)-(VII) are eliminated by treatment with 6M HCl at 90-5 C yielding L-2-amino-3-hydroxyaminopropionic acid (L)-(VIII), which is finally nitrosated with NaNO2 and HCl.
【1】 Serradell, M.N.; Castañer, J.; Cabanillas, F.; Blancafort, P.; Alanosine. Drugs Fut 1979, 4, 7, 469. |
【2】 Yoshikazu, I.; et al.; Synthesis of alanosine. Bull Chem Soc Jpn 1973, 46, 1847-50. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(D) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
(A) | 39517 | N-(benzyloxy)-4-methylbenzenesulfonamide | C14H15NO3S | 详情 | 详情 | |
(B) | 39520 | 1-(benzoyloxy)-2,5-pyrrolidinedione | C11H9NO4 | 详情 | 详情 | |
(L)-(V) | 39522 | N-((1S)-2-anilino-1-[[(benzyloxy)amino]methyl]-2-oxoethyl)benzamide | C23H23N3O3 | 详情 | 详情 | |
(L)-(VI) | 39523 | N-[(2S)-3-anilino-3-oxo-2-(propionylamino)propyl]-N-(benzyloxy)benzamide | C26H27N3O4 | 详情 | 详情 | |
(L)-(VII) | 39524 | N-((1S)-2-anilino-1-[[benzoyl(hydroxy)amino]methyl]-2-oxoethyl)benzamide | C23H21N3O4 | 详情 | 详情 | |
(L)-(VIII) | 39525 | (2S)-2-amino-3-(hydroxyamino)propionic acid | C3H8N2O3 | 详情 | 详情 | |
(I) | 18341 | ethyl 2,3-dibromopropanoate | 3674-13-3 | C5H8Br2O2 | 详情 | 详情 |
(II) | 39518 | 3-[(benzyloxy)[(4-methylphenyl)sulfonyl]amino]alanine | C17H20N2O5S | 详情 | 详情 | |
(III) | 39519 | 3-[(benzyloxy)amino]alanine | C10H14N2O3 | 详情 | 详情 | |
(IV) | 39521 | N-benzoyl-3-[(benzyloxy)amino]alanine | C17H18N2O4 | 详情 | 详情 | |
(C) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |