【结 构 式】 |
【分子编号】39512 【品名】[(2S,5R,6R)-5-amino-6-[((1R,2R,3S,4R,6S)-4,6-diamino-3-[[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl)oxy]tetrahydro-2H-pyran-2-yl]methylcarbamodithioic acid 【CA登记号】 |
【 分 子 式 】C20H39N5O7S2 【 分 子 量 】525.69116 【元素组成】C 45.7% H 7.48% N 13.32% O 21.3% S 12.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile. 2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol. 3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II), C1a which is reduced with LiAlH4 in refluxing THF.
【1】 Castaner, J.; Sweetman, A.J.; Serradell, M.N.; Blancafort, P.; Sagamicin. Drugs Fut 1979, 4, 5, 360. |
【2】 Matsushima, H.; et al.; JP 75123640 . |
【3】 Matsushima, H.; et al.; JP 75129531 . |
【4】 Matsushima, H.; et al.; JP 75126639 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 23403 | Methyl p-toluenesulfonate; Methyl 4-methylbenzenesulfonate; Methyl 4-toluenesulfonate | 80-48-8 | C8H10O3S | 详情 | 详情 |
(I) | 39511 | (2R,3R,4R,5R)-2-[((1S,2R,3R,4S,6R)-4,6-diamino-3-[[(2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl)oxy]-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol | C19H39N5O7 | 详情 | 详情 | |
(II) | 39512 | [(2S,5R,6R)-5-amino-6-[((1R,2R,3S,4R,6S)-4,6-diamino-3-[[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl)oxy]tetrahydro-2H-pyran-2-yl]methylcarbamodithioic acid | C20H39N5O7S2 | 详情 | 详情 |
Extended Information