(4S)-4-phenyl-4,5-dihydro-1H-imidazole-2-thiol; (4S)-4-phenyl-4,5-dihydro-1H-imidazol-2-ylhydrosulfide -Drug Synthesis Database

【结构式】

【分子编号】39498

【品名】(4S)-4-phenyl-4,5-dihydro-1H-imidazole-2-thiol; (4S)-4-phenyl-4,5-dihydro-1H-imidazol-2-ylhydrosulfide

【CA登记号】

【分子式】C₉H₁₀N₂S

【分子量】178.25788

【元素组成】C 60.64% H 5.65% N 15.72% S 17.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The cyclization of (S)-(+)-phenylethylenediamine (I) with CS2 in alkaline water gives (S)-(+)-4-phenyl-2-mercaptoimidazolidine (II), which is then cyclized again with 1,2-dibromoethane (A) in alkaline isopropanol-water.

参考文献中间体

合成目标

【1】 Castañer, J.; Hopkins, S.J.; Blancafort, P.; Serradell, M.N.; Levamisole hydrochloride. Drugs Fut 1979, 4, 6, 420.
【2】 Raeymaekers, A.H.M.; et al.; Absolute configurations of the optical isomers of the broad spectrum anthelmintic tetramisole. Tetrahedron Lett 1967, 16, 1467-70.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	10252	1,2-Dibromoethane; Ethylene dibromide	106-93-4	C₂H₄Br₂	详情	详情
(I)	39497	(1S)-1-phenyl-1,2-ethanediamine; (1S)-2-amino-1-phenylethylamine		C₈H₁₂N₂	详情	详情
(II)	39498	(4S)-4-phenyl-4,5-dihydro-1H-imidazole-2-thiol; (4S)-4-phenyl-4,5-dihydro-1H-imidazol-2-ylhydrosulfide		C₉H₁₀N₂S	详情	详情

Extended Information