• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】39477

【品名】2,3-dihydro-1,4-benzodioxin-2-ylmethanamine; 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine

【CA登记号】

【 分 子 式 】C9H11NO2

【 分 子 量 】165.19188

【元素组成】C 65.44% H 6.71% N 8.48% O 19.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

By condensation of 2-aminomethyl-1,4-benzodioxane (I) with 2,6-dimethoxyphenoxyethyl chloride (II) performed by heating at 160 C or by means of K2CO3 in refluxing CHCl3 - water. The starting products (I) and (II) are prepared as follows: 1) The reaction of 2-chloromethyl-1,4-benzodioxane (III) with potassium phthalimide (IV) in refluxing DMF gives 2-phthalimidomethyl-1,4-benzodioxane (V), which is then treated with hydrazine hydrate (A) in refluxing 2-ethoxyethanol to give (I). 2) The condensation of 2,6-dimethoxyphenol (VI) with ethylene carbonate (VII) by means of K2CO3 in refluxing toluene gives 2,6-dimethoxyphenoxyethanol (VIII), which is then refluxed with SOCl2 to afford (II).

1 US 3472874 .
2 Castaner, J.; Serradell, M.N.; Hillier, K.; Blancafort, P.; WB-4101. Drugs Fut 1979, 4, 5, 369.
3 Green, P.N.; et al.; Synthesis and pharmacological properties of a series of 2-(substituted-aminoethyl)-1,4-benzodioxanes. J Med Chem 1969, 12, 2, 326-329.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 27334 N-(2,5-dichloropentyl)-2-methoxy-5-[methyl(methylsulfonyl)amino]benzamide C15H22Cl2N2O4S 详情 详情
(I) 39477 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine; 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine C9H11NO2 详情 详情
(II) 39479 2-(2-chloroethoxy)-1,3-dimethoxybenzene; 2-(2-chloroethoxy)-3-methoxyphenyl methyl ether C10H13ClO3 详情 详情
(III) 39475 2-(chloromethyl)-2,3-dihydro-1,4-benzodioxine 2164-33-2 C9H9ClO2 详情 详情
(IV) 27890 Potassium phthalimide 1074-82-4 C8H4KNO2 详情 详情
(V) 39476 2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1H-isoindole-1,3(2H)-dione C17H13NO4 详情 详情
(VI) 20228 2,6-dimethoxyphenol 91-10-1 C8H10O3 详情 详情
(VII) 32802 1,3-dioxolan-2-one 96-49-1 C3H4O3 详情 详情
(VIII) 39478 2-(2,6-dimethoxyphenoxy)-1-ethanol C10H14O4 详情 详情
Extended Information