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【结 构 式】

【分子编号】39470

【品名】ethyl 2-[4-(2-chloroacetyl)phenyl]propanoate

【CA登记号】

【 分 子 式 】C13H15ClO3

【 分 子 量 】254.713

【元素组成】C 61.3% H 5.94% Cl 13.92% O 18.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Compound can be prepared in two different ways: 1) The cyclization of ethyl 2-[4-(chloroacetyl)phenyl]propionate (I) with 2-aminopyridine (II) in refluxing ethanol gives ethyl 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionate (III), which is then hydrolyzed with NaOH in refluxing ethanol water. 2) By cyclization of a mixture of pyridine (IV), hydroxylamine (V) and 2-[4-(chloroacetyl)phenyl]propionic acid (VI) by heating at 80-100 C.

1 Muro, T.; Ogawa K.; JP 7703954 .
2 Nakanishi, M.; et al.; US 3978071 .
3 Hillier, K.; Y-9213. Drugs Fut 1979, 4, 5, 373.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 39470 ethyl 2-[4-(2-chloroacetyl)phenyl]propanoate C13H15ClO3 详情 详情
(II) 11305 2-Pyridinamine; 2-Pyridinylamine; 2-Aminopyridine 504-29-0 C5H6N2 详情 详情
(III) 39471 ethyl 2-(4-imidazo[1,2-a]pyridin-2-ylphenyl)propanoate C18H18N2O2 详情 详情
(IV) 29669 Pyridine 110-86-1 C5H5N 详情 详情
(V) 32201 Hydroxylamine 7803-49-8 H3NO 详情 详情
(VI) 39472 2-[4-(2-chloroacetyl)phenyl]propionic acid C11H11ClO3 详情 详情
Extended Information