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【结 构 式】 
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【分子编号】39458 【品名】(1S,3S,7R,11S,12S,15S,17R,21R,23R,25S)-17-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1,11,21,25-tetrahydroxy-5,13-bis[(E)-2-methoxy-2-oxoethylidene]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate 【CA登记号】 |
【 分 子 式 】C51H80O16Si 【 分 子 量 】977.2721 【元素组成】C 62.68% H 8.25% O 26.19% Si 2.87% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LXVIII)The selective silylation of (LXVII) with TBMDSCl, Et3N and DMAP in DMF gives the 26-TBDMS ether (LXVIII), which is acetylated with Ac2O and pyridine yielding the 7-acetate (LXIX). Finally, (LXIX) is desilylated with HF in acetonitrile.
| 【1】 Pettit, G.R.; et al.; Synthetic conversion of bryostatin 2 to bryostatin 1 and related bryopyrans. Can J Chem 1991, 69, 856. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (LXVII) | 39457 | (1S,3S,7R,11S,12S,15S,17R,21R,23R,25S)-1,11,21,25-tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis[(E)-2-methoxy-2-oxoethylidene]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate | C45H66O16 | 详情 | 详情 | |
| (LXVIII) | 39458 | (1S,3S,7R,11S,12S,15S,17R,21R,23R,25S)-17-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1,11,21,25-tetrahydroxy-5,13-bis[(E)-2-methoxy-2-oxoethylidene]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate | C51H80O16Si | 详情 | 详情 | |
| (LXIX) | 39459 | (1S,3S,7R,11S,12S,15S,17R,21R,23R,25S)-25-(acetoxy)-17-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1,11,21-trihydroxy-5,13-bis[(E)-2-methoxy-2-oxoethylidene]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate | C53H82O17Si | 详情 | 详情 |
Extended Information