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【结 构 式】 
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【分子编号】39348 【品名】 【CA登记号】 |
【 分 子 式 】C10H20N6O5 【 分 子 量 】304.30624 【元素组成】C 39.47% H 6.62% N 27.62% O 26.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Coupling of Boc-d-nitroarginine (I) with sarcosine methyl ester (II) in the presence of EDC and HOBt gave dipeptide (III). Subsequent deprotection of the Boc group of (III) afforded amine (IV), which was coupled with benzylsulfonyl chloride (V), yielding sulfonamide (VI). Then, saponification of the methyl ester of (VI) with LiOH furnished carboxylic acid (VII).
| 【1】 Semple, J.E.; et al.; Novel, potent, and selective factor Xa inhibitors featuring a hydrophobic P1-ketoamide moiety. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 193. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39364 | Omega-nitro-Boc-D-arginine | 50913-12-7 | C11H21N5O6 | 详情 | 详情 |
| (II) | 10430 | methyl 2-(methylamino)acetate; methyl N-methylglycinate | 5473-12-1 | C4H9NO2 | 详情 | 详情 |
| (III) | 39347 | C15H28N6O7 | 详情 | 详情 | ||
| (IV) | 39348 | C10H20N6O5 | 详情 | 详情 | ||
| (V) | 25151 | phenylmethanesulfonyl chloride | 1939-99-7 | C7H7ClO2S | 详情 | 详情 |
| (VI) | 39349 | C17H26N6O7S | 详情 | 详情 | ||
| (VII) | 39350 | C16H24N6O7S | 详情 | 详情 |
Extended Information