• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】39318

【品名】3-isopropyl-4-methylpentanoic acid

【CA登记号】

【 分 子 式 】C9H18O2

【 分 子 量 】158.24072

【元素组成】C 68.31% H 11.47% O 20.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Addition of vinylmagnesium bromide to diisopropyl ketone (I) produced carbinol (II). Subsequent oxidation of (II) with pyridinium chlorochromate gave unsaturated aldehyde (III), which was further hydrogenated to the saturated aldehyde (IV). Optionally, oxidation with sodium chlorite produced carboxylic acid (V), which was converted to acid chloride (VI) using oxalyl chloride and pyridine.

1 Marquez, V.E.; Bienfait, B.; Lewin, N.E.; Benzaria, S.; Bhattacharyya, D.K.; Lee, J.; Nacro, K.; Han, K.-C.; Kang, J.-H.; Blumberg, P.M.; Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?. J Med Chem 2000, 43, 5, 921.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
16524 bromo(vinyl)magnesium 1826-67-1 C2H3BrMg 详情 详情
(I) 39314 2,4-dimethyl-3-pentanone 565-80-0 C7H14O 详情 详情
(II) 39315 3-isopropyl-4-methyl-1-penten-3-ol C9H18O 详情 详情
(III) 39316 3-isopropyl-4-methyl-2-pentenal C9H16O 详情 详情
(IV) 39317 3-isopropyl-4-methylpentanal C9H18O 详情 详情
(V) 39318 3-isopropyl-4-methylpentanoic acid C9H18O2 详情 详情
(VI) 39319 3-isopropyl-4-methylpentanoyl chloride C9H17ClO 详情 详情
Extended Information