N-[4-(2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl)phenyl]-4-(4-[hydroxy[4-(trifluoromethyl)phenyl]methyl]-2H-1,2,3-triazol-2-yl)benzenesulfonamide -Drug Synthesis Database

【结构式】

【分子编号】39313

【品名】N-[4-(2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl)phenyl]-4-(4-[hydroxy[4-(trifluoromethyl)phenyl]methyl]-2H-1,2,3-triazol-2-yl)benzenesulfonamide

【CA登记号】

【分子式】C₃₁H₂₉F₃N₆O₄S

【分子量】638.6705096

【元素组成】C 58.3% H 4.58% F 8.92% N 13.16% O 10.02% S 5.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

After reduction of (VIII) to alcohol (IX) with NaBH4, further alcohol reduction using triethylsilane and trifluoroacetic acid produced the title compound

参考文献中间体

合成目标

【1】 Parmee, E.R.; Ok, H.O.; Brockunier, L.L.; et al.; Human beta3-adrenergic receptor agonist containing 1,2,3-triazole-substituted benzenesulfonamides. Bioorg Med Chem Lett 2000, 10, 18, 2111.
【2】 Brockunier, L.L.; Parme, E.R.; Ok, H.O.; et al.; Human beta3 adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 252.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VIII)	39312	N-[4-(2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl)phenyl]-4-[4-[4-(trifluoromethyl)benzoyl]-2H-1,2,3-triazol-2-yl]benzenesulfonamide		C₃₁H₂₇F₃N₆O₄S	详情	详情
(IX)	39313	N-[4-(2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl)phenyl]-4-(4-[hydroxy[4-(trifluoromethyl)phenyl]methyl]-2H-1,2,3-triazol-2-yl)benzenesulfonamide		C₃₁H₂₉F₃N₆O₄S	详情	详情

Extended Information