【结 构 式】 |
【分子编号】39270 【品名】N-(2-aminobenzyl)-N-(1-benzyl-4-piperidinyl)amine; N-(2-aminobenzyl)-1-benzyl-4-piperidinamine 【CA登记号】 |
【 分 子 式 】C19H25N3 【 分 子 量 】295.42772 【元素组成】C 77.25% H 8.53% N 14.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)The reductive amination of 2-nitrobenzaldehyde (I) with 4-amino-1-benzylpiperidine (II) in the presence of NaBH4 gave amine (III). Subsequent hydrogenation of the nitro group of (III) over Rh/C afforded (IV), which was converted to oxoquinazoline (V) upon treatment with carbonyl diimidazole in hot DMF. Hydrogenolysis of the benzyl protecting group of (V) yielded intermediate (VI).
【1】 Eberlein, W.; Wienen, W.; Doods, H.; Rudolf, K.; Entzeroth, M.; Pieper, H.; Engel, W.; Hallermayer, G. (Dr. Karl Thomae GmbH); Modified aminoacids, pharmaceuticals containing these cpds. and methods for their production. JP 2000505100; WO 9811128 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 11370 | 2-Nitrobenzaldehyde | 552-89-6 | C7H5NO3 | 详情 | 详情 |
(II) | 34808 | 1-Benzyl-4-piperidinylamine; 1-Benzyl-4-piperidinamine; 4-Amino-1-benzylpiperidine | 50541-93-0 | C12H18N2 | 详情 | 详情 |
(III) | 39269 | 1-benzyl-N-(2-nitrobenzyl)-4-piperidinamine; N-(1-benzyl-4-piperidinyl)-N-(2-nitrobenzyl)amine | C19H23N3O2 | 详情 | 详情 | |
(IV) | 39270 | N-(2-aminobenzyl)-N-(1-benzyl-4-piperidinyl)amine; N-(2-aminobenzyl)-1-benzyl-4-piperidinamine | C19H25N3 | 详情 | 详情 | |
(V) | 39271 | 3-(1-benzyl-4-piperidinyl)-3,4-dihydro-2(1H)-quinazolinone | C20H23N3O | 详情 | 详情 | |
(VI) | 39272 | 3-(4-piperidinyl)-3,4-dihydro-2(1H)-quinazolinone | C13H17N3O | 详情 | 详情 |
Extended Information