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【结 构 式】 
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【分子编号】39124 【品名】3-methyl-7-(5-oxohexyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione 【CA登记号】 |
【 分 子 式 】C15H22N4O3 【 分 子 量 】306.36484 【元素组成】C 58.81% H 7.24% N 18.29% O 15.67% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)By treating 3-methylxanthine (I) with sodium hydroxide and 1-bromo-5-hexanone (II) to give 3-methyl-7-(5-oxohexyl)xanthine (III), which is reacted to (IV) with 1-bromopropane (A) in the same way. Compound (IV) is reduced to the title compound with sodium borohydride.
| 【1】 Unterhalt, B.; HWA-153. Drugs Fut 1980, 5, 2, 77. |
| 【2】 Stefanovich, V.; Private Communication 2002, 10, 9, 3001. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 19502 | Propyl bromide; 1-Bromopropane | 106-94-5 | C3H7Br | 详情 | 详情 |
| (I) | 39122 | 3-methyl-3,7-dihydro-1H-purine-2,6-dione | 1076-22-8 | C6H6N4O2 | 详情 | 详情 |
| (II) | 37057 | 6-bromo-2-hexanone | C6H11BrO | 详情 | 详情 | |
| (III) | 39123 | 3-methyl-7-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione | C12H16N4O3 | 详情 | 详情 | |
| (IV) | 39124 | 3-methyl-7-(5-oxohexyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione | C15H22N4O3 | 详情 | 详情 |
Extended Information