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【结 构 式】 
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【分子编号】39071 【品名】8-amino-5-hydroxy-3,4-dihydro-2(1H)-quinolinone 【CA登记号】 |
【 分 子 式 】C9H10N2O2 【 分 子 量 】178.19068 【元素组成】C 60.66% H 5.66% N 15.72% O 17.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)The diketone (IV) can also be obtained as follows: the nitration of 5-hydroxy-3,4-dihydrocarbostyril (IX) with HNO3 in acetic acid - acetic anhydride gives 5-hydroxy-8-nitro-3,4-dihydrocarbostyril (X), which is reduced with H2 over Pd/C affording 5-hydroxy-8-amino-3,4-dihydrocarbostyril (Xl). Finally, this compound is oxidized with FeCl3 in aqueous HCl.
| 【1】 Uchida, M.; et al.; Synthesis of 5-(3-tert-butylamino-2-hydroxypropxy)-8-3,4-dihydrocarbostyril hydochloride and its beta-adrenergic blocking agent. Yakugaku Zasshi 1976, 96, 5, 571-577. |
| 【2】 Castaner, J.; Blancafort, P.; Serradell, M.N.; 8-Hydroxycarteolol. Drugs Fut 1980, 5, 2, 78. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 39065 | 3,4,4a,8a-tetrahydro-2,5,8(1H)-quinolinetrione | C9H9NO3 | 详情 | 详情 | |
| (IX) | 31477 | 5-hydroxy-3,4-dihydro-2(1H)-quinolinone | C9H9NO2 | 详情 | 详情 | |
| (X) | 39070 | 5-hydroxy-8-nitro-3,4-dihydro-2(1H)-quinolinone | C9H8N2O4 | 详情 | 详情 | |
| (XI) | 39071 | 8-amino-5-hydroxy-3,4-dihydro-2(1H)-quinolinone | C9H10N2O2 | 详情 | 详情 |
Extended Information