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【结 构 式】 
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【分子编号】39012 【品名】N(1)-[2-([2-[(6-aminohexyl)amino]ethyl]disulfanyl)ethyl]-1,6-hexanediamine; N-(6-aminohexyl)-N-[2-([2-[(6-aminohexyl)amino]ethyl]disulfanyl)ethyl]amine 【CA登记号】 |
【 分 子 式 】C16H38N4S2 【 分 子 量 】350.63668 【元素组成】C 54.81% H 10.92% N 15.98% S 18.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)N-(6-Aminohexyl)cysteamine (I), synthesized according to Wineman et al., is converted to the disulfide (II) by potassium ferricyanide oxidation. The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).
| 【3】 Benfey, B.G.; Melchiorre, C.; Belleau, B.; Yong, M.S.; Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides. J Med Chem 1978, 21, 11, 1126-32. |
| 【1】 Benfey, B.G.; Benextramine. Drugs Fut 1981, 6, 12, 751. |
| 【2】 James, J.C.; Wineman, R.J.; Pomponi, A.M.; Gollis, M.H.; Thiolethylation of amines with ethylene disulfide. J Org Chem 1962, 27, 4222-26. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39011 | 2-[(6-aminohexyl)amino]ethylhydrosulfide; 2-[(6-aminohexyl)amino]-1-ethanethiol | C8H20N2S | 详情 | 详情 | |
| (II) | 39012 | N(1)-[2-([2-[(6-aminohexyl)amino]ethyl]disulfanyl)ethyl]-1,6-hexanediamine; N-(6-aminohexyl)-N-[2-([2-[(6-aminohexyl)amino]ethyl]disulfanyl)ethyl]amine | C16H38N4S2 | 详情 | 详情 | |
| (III) | 12568 | 2-Methoxybenzaldehyde; o-Methoxybenzaldehyde | 135-02-4 | C8H8O2 | 详情 | 详情 |
| (IV) | 39013 | 1,24-bis(2-methoxyphenyl)-12,13-dithia-2,9,16,23-tetraazatetracosane-1,24-diol | C32H54N4O4S2 | 详情 | 详情 |
Extended Information