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【结 构 式】

【分子编号】38992

【品名】8-bromooctanoyl chloride

【CA登记号】

【 分 子 式 】C8H14BrClO

【 分 子 量 】241.55526

【元素组成】C 39.78% H 5.84% Br 33.08% Cl 14.68% O 6.62%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

Friedel-Crafts acylation of chlorobenzene (VIII) with 8-bromooctanoyl chloride (IX) in the presence of AlCl3 gave rise to bromo ketone (X). Finally, alkylation of thiouracil (VII) with bromoketone (X) generated the title compound.

1 Hickey, D.M.B.; Boyd, H.F.; Flynn, S.T.; et al.; 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett 2000, 10, 4, 395.
2 Pinto, I.L.; Ife, R.J.; Hickey, D.M.B.; Smith, S.A.; Leach, C.A.; Porter, R.A. (SmithKline Beecham plc); Pyrimidinone cpds. and pharmaceutical compsns. containing them. EP 1028955; WO 9924420 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VII) 38991 5-(5-pyrimidinylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone C9H8N4OS 详情 详情
(VIII) 10190 1-Chlorobenzene 108-90-7 C6H5Cl 详情 详情
(IX) 38992 8-bromooctanoyl chloride C8H14BrClO 详情 详情
(X) 38993 8-bromo-1-(4-chlorophenyl)-1-octanone C14H18BrClO 详情 详情
Extended Information