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【结 构 式】

【分子编号】38943

【品名】tert-butyl (E)-3-(4-[4-[4-[(E)-3-(tert-butoxy)-3-oxo-1-propenyl]phenyl]-2-[4-(diethylamino)phenyl]-1H-imidazol-5-yl]phenyl)-2-propenoate

【CA登记号】

【 分 子 式 】C39H45N3O4

【 分 子 量 】619.80412

【元素组成】C 75.58% H 7.32% N 6.78% O 10.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Coupling of tert-butyl acrylate (II) with 4,4'-dibromobenzyl (I) using palladium diacetate and tri-o-tolyl phosphine produced diester (III). Subsequent condensation of (III) with 4-(diethylamino)benzaldehyde (IV) in the presence of ammonium acetate generated the required imidazole system (V). Finally, deprotection of the tert-butyl esters of (V) by treatment with trifluoroacetic acid afforded the title dicarboxylic acid.

1 Mjalli, A.; Sarshar, S.; Cao, X.; Bakir, F. (Ontogen Corp.); Modulators of proteins with phosphotyrosine recognition units. US 5753687; US 5770620 .
2 Mjalli, A.; Sarshar, S.; Bakir, F.; Cao, X. (Ontogen Corp.); Modulators of proteins with phosphotyrosine recognition units. WO 9827065 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 38940 1,2-bis(4-bromophenyl)-1,2-ethanedione 35578-47-3 C14H8Br2O2 详情 详情
(II) 12760 tert-butyl acrylate 1663-39-4 C7H12O2 详情 详情
(III) 38941 tert-butyl (E)-3-[4-(2-[4-[(E)-3-(tert-butoxy)-3-oxo-1-propenyl]phenyl]-2-oxoacetyl)phenyl]-2-propenoate C28H30O6 详情 详情
(IV) 38942 N,N-Diethyl-p-aminobenzaldehyde; 4-(diethylamino)benzaldehyde 120-21-8 C11H15NO 详情 详情
(V) 38943 tert-butyl (E)-3-(4-[4-[4-[(E)-3-(tert-butoxy)-3-oxo-1-propenyl]phenyl]-2-[4-(diethylamino)phenyl]-1H-imidazol-5-yl]phenyl)-2-propenoate C39H45N3O4 详情 详情
Extended Information