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【结 构 式】

【分子编号】38871

【品名】1,4-dioxane-2,6-dione

【CA登记号】4480-83-5

【 分 子 式 】C4H4O4

【 分 子 量 】116.07336

【元素组成】C 41.39% H 3.47% O 55.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Condensation of diglycolic anhydride (I) with 1-amino-2-methylpropane-2-thiol (II) afforded amide (III). Subsequent nitrosation of the thiol group of (III) employing tert-butyl nitrite gave the nitrosothio derivative (IV). This was then condensed with 4-[2-(dimethylamino)ethoxy]-2-methyl-5-isopropylphenol (VI), prepared by basic hydrolysis of moxisylyte (V), and the resulting compound was finally converted to the succinate salt.

1 Earl, R.A.; et al.; Nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of erectile dysfunction. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 239.
2 Gaston, R.D.; Saenz de Tejada, I.; Schroeder, J.D.; Shelekhin, T.E.; Garvey, D.S.; Wang, T. (NitroMed Inc.); Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compsns. and methods of use. WO 0012075 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 38871 1,4-dioxane-2,6-dione 4480-83-5 C4H4O4 详情 详情
(II) 38872 1-amino-2-methyl-2-propanethiol; 2-amino-1,1-dimethylethylhydrosulfide C4H11NS 详情 详情
(III) 38873 2-[2-[(2-methyl-2-sulfanylpropyl)amino]-2-oxoethoxy]acetic acid C8H15NO4S 详情 详情
(IV) 38874 2-(2-[[2-methyl-2-(nitrososulfanyl)propyl]amino]-2-oxoethoxy)acetic acid C8H14N2O5S 详情 详情
(V) 38875 4-[2-(dimethylamino)ethoxy]-5-isopropyl-2-methylphenyl acetate C16H25NO3 详情 详情
(VI) 38876 4-[2-(dimethylamino)ethoxy]-5-isopropyl-2-methylphenol C14H23NO2 详情 详情
Extended Information