1a-methyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione -Drug Synthesis Database

【结构式】

【分子编号】38867

【品名】1a-methyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione

【CA登记号】

【分子式】C₁₁H₈O₃

【分子量】188.18272

【元素组成】C 70.21% H 4.28% O 25.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

In an alternative procedure, the title compound was obtained by addition of 2-mercaptoethanol (III) to vitamin K3 oxide (menadione oxide) (IV) in the presence of imidazole.

参考文献中间体

合成目标

【1】 Horikawa, A.; et al.; Synthesis of protein tyrosine phosphatase inhibitor and application for malignant pediatric tumor. 21st Symp Med Chem (Nov 28 2001, Kyoto) 2001, Abst 2P-05.
【2】 Kerns, J.; Carr, B.; Dowd, P.; Finn, F.M.; Naganathan, s.; Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells. Bioorganic Chemistry 1995, 23, 2, 101.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	36375	2-Sulfanyl-1-ethanol; 2-Mercaptoethanol	60-24-2	C₂H₆OS	详情	详情
(IV)	38867	1a-methyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione		C₁₁H₈O₃	详情	详情

Extended Information