menadione; 2-methylnaphthoquinone -Drug Synthesis Database

【结构式】

【分子编号】38865

【品名】menadione; 2-methylnaphthoquinone

【CA登记号】58-27-5

【分子式】C₁₁H₈O₂

【分子量】172.18332

【元素组成】C 76.73% H 4.68% O 18.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Halogenation of vitamin K3 (menadione) (I) by means of bromine and NaOAc in AcOH furnished 3-bromo menadione (II). Subsequent displacement of the halogen of (II) by 2-mercaptoethanol (III) in the presence of imidazole yielded the desired (2-hydroxyethyl) thioether.

参考文献中间体

合成目标

【1】 Kerns, J.K.; Carr, B.I.; Wilcox, C.S. (University of Pittsburgh); Antiproliferative naphthoquinones, derivs., compsns., and uses thereof. WO 0008495 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	38865	menadione; 2-methylnaphthoquinone	58-27-5	C₁₁H₈O₂	详情	详情
(II)	38866	2-bromo-3-methylnaphthoquinone		C₁₁H₇BrO₂	详情	详情
(III)	36375	2-Sulfanyl-1-ethanol; 2-Mercaptoethanol	60-24-2	C₂H₆OS	详情	详情

Extended Information