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【结 构 式】 
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【分子编号】38521 【品名】methyl (3R,6S,9R,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate 【CA登记号】 |
【 分 子 式 】C11H18N2O3S 【 分 子 量 】258.3416 【元素组成】C 51.14% H 7.02% N 10.84% O 18.58% S 12.41% |
合成路线1
该中间体在本合成路线中的序号：(XIa)Treatment of 5-methylpyridine-2-carbonitrile (I) with ethanol and sulfuric acid gave ester (II), which was further hydrolyzed to carboxylic acid (III) using aqueous HCl. Hydrogenation of the pyridine ring of (III) over PtO2 yielded a 3:1 mixture of cis and trans piperidines as the corresponding hydrochloride salts (IV). Liberation of the free base by means of Et3N in a suspension in CH2Cl2 allowed the separation of the racemic cis isomer, which was N-acylated with Ac2O to give acetamide (V). Esterification of (V) with isobutylene in the presence of H2SO4 afforded the tert-butyl ester (VI). The electrochemical oxidation of (VI) in MeOH produced the 6-methoxy piperidine (VII). Ring opening of the piperidine (VII) with formation of the thiazolidine ring upon treatment with methyl L-cysteinate (VIII) generated the tert-butoxycarbonylbutyl thiazolidine (IXa-h) as a complex mixture of diastereoisomers. After cleavage of the tert-butyl ester of (IXa-h) with trifluoroacetic acid, cyclization using 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ) gave rise to the thiazoloazepine bicyclic system (Xa-d). Column chromatography of the resulting diastereomeric mixture provided the (6S,9R) and (6S,9S) isomers in a 1:2 ratio. Hydrolysis of this mixture with methanolic HCl yielded the bicyclic amine (XIa-b). Coupling of (XIa-b) with (2S,3S)-2-acetylthio-3-methylpentanoic acid (XII) gave the corresponding mixture of amides, from which the desired isomer (XIII) was isolated by column chromatography. Finally, hydrolysis of methyl ester and tioacetate ester groups of (XIII) using LiOH gave rise to the title compound.
| 【1】 Oinuma, H.; Suda, S.; Yoneda, N.; Kotake, M.; Mizuno, M.; Matsuhima, T.; Fukuda, Y.; Saito, M.; Matsuoka, T.; Adachi, H.; Namiki, M.; Sudo, T.; Miyake, K.; Okita, M. (Eisai Co., Ltd.); Substd. thiazolo[3,2-alpha]azepine deriv.. EP 0719779; JP 1996027156; JP 1996059672; JP 1996165293; US 5789403; WO 9602549 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IXa) | 38509 | methyl (2S,4R)-2-[(1R,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXb) | 38510 | methyl (2S,4R)-2-[(1R,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXc) | 38511 | methyl (2R,4R)-2-[(1R,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXd) | 38512 | methyl (2R,4R)-2-[(1R,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXe) | 38513 | methyl (2S,4R)-2-[(1S,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXf) | 38514 | methyl (2S,4R)-2-[(1S,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXg) | 38515 | methyl (2R,4R)-2-[(1S,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXh) | 38516 | methyl (2R,4R)-2-[(1S,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (Xa) | 38517 | methyl (3R,6S,9R,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (Xb) | 38518 | methyl (3R,6R,9R,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (Xd) | 38520 | methyl (3R,6R,9S,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (XIa) | 38521 | methyl (3R,6S,9R,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 | |
| (XIb) | 38522 | methyl (3R,6S,9S,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 | |
| (I) | 38502 | 5-methyl-2-pyridinecarbonitrile | C7H6N2 | 详情 | 详情 | |
| (II) | 38503 | ethyl 5-methyl-2-pyridinecarboxylate | C9H11NO2 | 详情 | 详情 | |
| (III) | 38504 | 5-methyl-2-pyridinecarboxylic acid | C7H7NO2 | 详情 | 详情 | |
| (IV) | 38505 | 5-methyl-2-piperidinecarboxylic acid | C7H13NO2 | 详情 | 详情 | |
| (V) | 38506 | (2S,5S)-1-acetyl-5-methyl-2-piperidinecarboxylic acid | C9H15NO3 | 详情 | 详情 | |
| (VI) | 38507 | tert-butyl (2S,5S)-1-acetyl-5-methyl-2-piperidinecarboxylate | C13H23NO3 | 详情 | 详情 | |
| (VII) | 38508 | tert-butyl (2S,5S)-1-acetyl-6-methoxy-5-methyl-2-piperidinecarboxylate | C14H25NO4 | 详情 | 详情 | |
| (VIII) | 27413 | methyl (2R)-2-amino-3-sulfanylpropanoate | C4H9NO2S | 详情 | 详情 | |
| (XII) | 35122 | (2S,3S)-2-(acetylsulfanyl)-3-methylpentanoic acid | C8H14O3S | 详情 | 详情 | |
| (XIII) | 38523 | methyl (3R,6S,9R,9aR)-6-[[(2S,3S)-2-(acetylsulfanyl)-3-methylpentanoyl]amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C19H30N2O5S2 | 详情 | 详情 | |
| (Xc) | 38519 | methyl (3R,6S,9S,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XXXIII)In a related method, L-pipecolic acid (XXVI) was protected as the methyl carbamate, followed by esterification with isobutylene to give (XXVII). Oxidation of (XXVII) with NaIO4 in the presence of RuO2 generated the 6-oxopipecolic acid derivative (XXVIII), which was subsequently methylated to yield (XXIX) as the major diastereoisomer. Reduction of (XXIX) with DIBAL afforded the cyclic aminal (XXX). Condensation of (XXX) with methyl L-cysteinate (VIII) gave thiazolidine (XXXIa-b). After tert-butyl ester cleavage in (XXXIa-b) with trifluoroacetic acid, cyclization by means of EEDQ produced the bicyclic system (XXXII). Deprotection of the methyl carbamate group of (XXXII) was carried out using methanesulfonic acid in the presence of dimethyl sulfide to afford amine (XXXIII). Coupling of (XXXIII) with (2S,3S)-2-acetylthio-3-methylpentanoic acid (XII) gave the corresponding mixture of amides, from which the desired isomer (XIII) was isolated by column chromatography. Finally, hydrolysis of methyl ester and tioacetate ester groups of (XIII) using LiOH gave rise to the title compound.
| 【1】 Oinuma, H.; Kotake, M.; Suda, S.; et al.; Discovery of a novel and orally active dual inhibitor of NEP and ACE: Synthesis and pharmacology. 217th ACS Natl Meet (March 21 1999, Anaheim) 2000, Abst MEDI 111. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXXIa) | 38528 | methyl (2R,4R)-2-[(1R,4S)-5-(tert-butoxy)-4-[(methoxycarbonyl)amino]-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O6S | 详情 | 详情 | |
| (XXXIb) | 38529 | methyl (2S,4R)-2-[(1R,4S)-5-(tert-butoxy)-4-[(methoxycarbonyl)amino]-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O6S | 详情 | 详情 | |
| (VIII) | 27413 | methyl (2R)-2-amino-3-sulfanylpropanoate | C4H9NO2S | 详情 | 详情 | |
| (XII) | 35122 | (2S,3S)-2-(acetylsulfanyl)-3-methylpentanoic acid | C8H14O3S | 详情 | 详情 | |
| (XIII) | 38523 | methyl (3R,6S,9R,9aR)-6-[[(2S,3S)-2-(acetylsulfanyl)-3-methylpentanoyl]amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C19H30N2O5S2 | 详情 | 详情 | |
| (XXVI) | 17380 | (2S)hexahydro-2-pyridinecarboxylic acid; (S)-pipecolic acid | 3105-95-1 | C6H11NO2 | 详情 | 详情 |
| (XXVII) | 38524 | 2-(tert-butyl) 1-methyl (2S)-1,2-piperidinedicarboxylate | C12H21NO4 | 详情 | 详情 | |
| (XXVIII) | 38525 | 2-(tert-butyl) 1-methyl (2S)-6-oxo-1,2-piperidinedicarboxylate | C12H19NO5 | 详情 | 详情 | |
| (XXIX) | 38526 | 2-(tert-butyl) 1-methyl (2S,5R)-5-methyl-6-oxo-1,2-piperidinedicarboxylate | C13H21NO5 | 详情 | 详情 | |
| (XXX) | 38527 | 2-(tert-butyl) 1-methyl (2S,5R)-6-hydroxy-5-methyl-1,2-piperidinedicarboxylate | C13H23NO5 | 详情 | 详情 | |
| (XXXII) | 38530 | methyl (3R,6S,9R,9aR)-6-[(methoxycarbonyl)amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O5S | 详情 | 详情 | |
| (XXXIII) | 38521 | methyl (3R,6S,9R,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XIa)Treatment of 5-methylpyridine-2-carbonitrile (I) with ethanol and sulfuric acid gave ester (II), which was further hydrolyzed to carboxylic acid (III) using aqueous HCl. Hydrogenation of the pyridine ring of (III) over PtO2 yielded a 3:1 mixture of cis and trans piperidines as the corresponding hydrochloride salts (IVa-b). Liberation of the free base of (IVa-b) by means of Et3N in a suspension in CH2Cl2 allowed the separation of the racemic cis isomer, which was N-acylated with Ac2O to give acetamide (V). Esterification of (V) with isobutylene in the presence of H2SO4 afforded the tert-butyl ester (VI). The electrochemical oxidation of (VI) in MeOH produced the 6-methoxy piperidine (VII). Ring opening of the piperidine (VII) with formation of the thiazolidine ring upon treatment with methyl L-cysteinate (VIII) generated the tert-butoxycarbonylbutyl thiazolidine (IXa-h) as a complex mixture of diastereoisomers. After cleavage of the tert-butyl ester of (IXa-h) with trifluoroacetic acid, cyclization using 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ) gave rise to the thiazoloazepine bicyclic system (Xa-d). Column chromatography of the resulting diastereomeric mixture provided the (6S,9R) and (6S,9S) isomers in a 1:2 ratio. Hydrolysis of this mixture with methanolic HCl yielded the bicyclic amine (XIa-b). Coupling of (XIa-b) with (2S,3S)-2-acetylthio-3-methylpentanoic acid (XII) gave the corresponding mixture of amides, from which the desired isomer (XIII) was isolated by column chromatography. Hydrolysis of methyl ester and thioacetate ester groups of (XIII) using LiOH, followed by S-acetylation with Ac2O in the presence of CoCl2 gave rise to the title compound.
| 【1】 Oinuma, H.; Suda, S.; Yoneda, N.; Kotake, M.; Mizuno, M.; Matsuhima, T.; Fukuda, Y.; Saito, M.; Matsuoka, T.; Adachi, H.; Namiki, M.; Sudo, T.; Miyake, K.; Okita, M. (Eisai Co., Ltd.); Substd. thiazolo[3,2-alpha]azepine deriv.. EP 0719779; JP 1996027156; JP 1996059672; JP 1996165293; US 5789403; WO 9602549 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IXa) | 38509 | methyl (2S,4R)-2-[(1R,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXb) | 38510 | methyl (2S,4R)-2-[(1R,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXc) | 38511 | methyl (2R,4R)-2-[(1R,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXd) | 38512 | methyl (2R,4R)-2-[(1R,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXe) | 38513 | methyl (2S,4R)-2-[(1S,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXf) | 38514 | methyl (2S,4R)-2-[(1S,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXg) | 38515 | methyl (2R,4R)-2-[(1S,4S)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (IXh) | 38516 | methyl (2R,4R)-2-[(1S,4R)-4-(acetamido)-5-(tert-butoxy)-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O5S | 详情 | 详情 | |
| (Xa) | 38517 | methyl (3R,6S,9R,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (Xb) | 38518 | methyl (3R,6R,9R,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (Xd) | 38520 | methyl (3R,6R,9S,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 | |
| (XIa) | 38521 | methyl (3R,6S,9R,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 | |
| (XIb) | 38522 | methyl (3R,6S,9S,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 | |
| (I) | 38502 | 5-methyl-2-pyridinecarbonitrile | C7H6N2 | 详情 | 详情 | |
| (II) | 38503 | ethyl 5-methyl-2-pyridinecarboxylate | C9H11NO2 | 详情 | 详情 | |
| (III) | 38504 | 5-methyl-2-pyridinecarboxylic acid | C7H7NO2 | 详情 | 详情 | |
| (IV) | 38505 | 5-methyl-2-piperidinecarboxylic acid | C7H13NO2 | 详情 | 详情 | |
| (V) | 38506 | (2S,5S)-1-acetyl-5-methyl-2-piperidinecarboxylic acid | C9H15NO3 | 详情 | 详情 | |
| (VI) | 38507 | tert-butyl (2S,5S)-1-acetyl-5-methyl-2-piperidinecarboxylate | C13H23NO3 | 详情 | 详情 | |
| (VII) | 38508 | tert-butyl (2S,5S)-1-acetyl-6-methoxy-5-methyl-2-piperidinecarboxylate | C14H25NO4 | 详情 | 详情 | |
| (VIII) | 27413 | methyl (2R)-2-amino-3-sulfanylpropanoate | C4H9NO2S | 详情 | 详情 | |
| (XII) | 35122 | (2S,3S)-2-(acetylsulfanyl)-3-methylpentanoic acid | C8H14O3S | 详情 | 详情 | |
| (XIII) | 38523 | methyl (3R,6S,9R,9aR)-6-[[(2S,3S)-2-(acetylsulfanyl)-3-methylpentanoyl]amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C19H30N2O5S2 | 详情 | 详情 | |
| (Xc) | 38519 | methyl (3R,6S,9S,9aR)-6-(acetamido)-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O4S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(XXI)In a related method, L-pipecolic acid (XIV) was protected as the methyl carbamate, followed by esterification with isobutylene to give (XV). Oxidation of (XV) with NaIO4 in the presence of RuO2 generated the 6-oxopipecolic acid derivative (XVI), which was subsequently methylated to yield (XVII) as the major diastereoisomer. Reduction of (XVII) with DIBAL afforded the cyclic aminal (XVIII). Condensation of (XVIII) with methyl L-cysteinate (VIII) gave thiazolidine (XIXa-b). After tert-butyl ester cleavage in (XIXa-b) with trifluoroacetic acid, cyclization by means of EEDQ produced the bicyclic system (XX). Deprotection of the methyl carbamate group of (XX) was carried out using methanesulfonic acid in the presence of dimethyl sulfide to afford amine (XXI). Coupling of (XXI) with (2S,3S)-2-acetylthio-3-methylpentanoic acid (XII) gave the corresponding mixture of amides, from which the desired isomer (XIII) was isolated by column chromatography. Hydrolysis of methyl ester and thioacetate ester groups of (XIII) using LiOH, followed by S-acetylation with Ac2O in the presence of CoCl2 gave rise to the title compound.
| 【1】 Oinuma, H.; Kotake, M.; Suda, S.; et al.; Discovery of a novel and orally active dual inhibitor of NEP and ACE: Synthesis and pharmacology. 217th ACS Natl Meet (March 21 1999, Anaheim) 2000, Abst MEDI 111. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIXa) | 38528 | methyl (2R,4R)-2-[(1R,4S)-5-(tert-butoxy)-4-[(methoxycarbonyl)amino]-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O6S | 详情 | 详情 | |
| (XIXb) | 38529 | methyl (2S,4R)-2-[(1R,4S)-5-(tert-butoxy)-4-[(methoxycarbonyl)amino]-1-methyl-5-oxopentyl]-1,3-thiazolidine-4-carboxylate | C17H30N2O6S | 详情 | 详情 | |
| (VIII) | 27413 | methyl (2R)-2-amino-3-sulfanylpropanoate | C4H9NO2S | 详情 | 详情 | |
| (XII) | 35122 | (2S,3S)-2-(acetylsulfanyl)-3-methylpentanoic acid | C8H14O3S | 详情 | 详情 | |
| (XIII) | 38523 | methyl (3R,6S,9R,9aR)-6-[[(2S,3S)-2-(acetylsulfanyl)-3-methylpentanoyl]amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C19H30N2O5S2 | 详情 | 详情 | |
| (XIV) | 17380 | (2S)hexahydro-2-pyridinecarboxylic acid; (S)-pipecolic acid | 3105-95-1 | C6H11NO2 | 详情 | 详情 |
| (XV) | 38524 | 2-(tert-butyl) 1-methyl (2S)-1,2-piperidinedicarboxylate | C12H21NO4 | 详情 | 详情 | |
| (XVI) | 38525 | 2-(tert-butyl) 1-methyl (2S)-6-oxo-1,2-piperidinedicarboxylate | C12H19NO5 | 详情 | 详情 | |
| (XVII) | 38526 | 2-(tert-butyl) 1-methyl (2S,5R)-5-methyl-6-oxo-1,2-piperidinedicarboxylate | C13H21NO5 | 详情 | 详情 | |
| (XVIII) | 38527 | 2-(tert-butyl) 1-methyl (2S,5R)-6-hydroxy-5-methyl-1,2-piperidinedicarboxylate | C13H23NO5 | 详情 | 详情 | |
| (XX) | 38530 | methyl (3R,6S,9R,9aR)-6-[(methoxycarbonyl)amino]-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C13H20N2O5S | 详情 | 详情 | |
| (XXI) | 38521 | methyl (3R,6S,9R,9aR)-6-amino-9-methyl-5-oxooctahydro[1,3]thiazolo[3,2-a]azepine-3-carboxylate | C11H18N2O3S | 详情 | 详情 |