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【结 构 式】

【分子编号】38452

【品名】4-bromo-1,2-dimethoxybenzene; 4-bromo-2-methoxyphenyl methyl ether

【CA登记号】2859-78-1

【 分 子 式 】C8H9BrO2

【 分 子 量 】217.06226

【元素组成】C 44.27% H 4.18% Br 36.81% O 14.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Organozinc reagent (II), prepared from 4-bromo-1,2-dimethoxybenzene (I), was coupled with methyl iodobenzoate (III) in the presence of bis(triphenylphosphine) palladium dichloride and diisobutylaluminum hydride to furnish biphenyl derivative (IV). After saponification of the methyl ester group of (IV), treatment with thionyl chloride yielded acid chloride (V).

1 Gong, Y.; Guertin, K.R.; McGarry, D.G.; Pauls, H.W.; Klein, S.I.; Spada, A.P. (Aventis Pharmaceuticals, Inc.); Substd. N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides. CA 2264556; EP 0931060; WO 9900356 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 38452 4-bromo-1,2-dimethoxybenzene; 4-bromo-2-methoxyphenyl methyl ether 2859-78-1 C8H9BrO2 详情 详情
(II) 38453 chloro(3,4-dimethoxyphenyl)zinc C8H9ClO2Zn 详情 详情
(III) 16123 methyl 4-iodobenzoate 619-44-3 C8H7IO2 详情 详情
(IV) 38454 methyl 3',4'-dimethoxy[1,1'-biphenyl]-4-carboxylate C16H16O4 详情 详情
(V) 38455 3',4'-dimethoxy[1,1'-biphenyl]-4-carbonyl chloride C15H13ClO3 详情 详情
Extended Information