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【结 构 式】 
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【分子编号】38452 【品名】4-bromo-1,2-dimethoxybenzene; 4-bromo-2-methoxyphenyl methyl ether 【CA登记号】2859-78-1 |
【 分 子 式 】C8H9BrO2 【 分 子 量 】217.06226 【元素组成】C 44.27% H 4.18% Br 36.81% O 14.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Organozinc reagent (II), prepared from 4-bromo-1,2-dimethoxybenzene (I), was coupled with methyl iodobenzoate (III) in the presence of bis(triphenylphosphine) palladium dichloride and diisobutylaluminum hydride to furnish biphenyl derivative (IV). After saponification of the methyl ester group of (IV), treatment with thionyl chloride yielded acid chloride (V).
| 【1】 Gong, Y.; Guertin, K.R.; McGarry, D.G.; Pauls, H.W.; Klein, S.I.; Spada, A.P. (Aventis Pharmaceuticals, Inc.); Substd. N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides. CA 2264556; EP 0931060; WO 9900356 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 38452 | 4-bromo-1,2-dimethoxybenzene; 4-bromo-2-methoxyphenyl methyl ether | 2859-78-1 | C8H9BrO2 | 详情 | 详情 |
| (II) | 38453 | chloro(3,4-dimethoxyphenyl)zinc | C8H9ClO2Zn | 详情 | 详情 | |
| (III) | 16123 | methyl 4-iodobenzoate | 619-44-3 | C8H7IO2 | 详情 | 详情 |
| (IV) | 38454 | methyl 3',4'-dimethoxy[1,1'-biphenyl]-4-carboxylate | C16H16O4 | 详情 | 详情 | |
| (V) | 38455 | 3',4'-dimethoxy[1,1'-biphenyl]-4-carbonyl chloride | C15H13ClO3 | 详情 | 详情 |
Extended Information