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【结 构 式】 
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【分子编号】42371 【品名】benzyl (3S)-3-[[tert-butyl(diphenyl)silyl]oxy]-4-[(2S)oxiranyl]butyl ether; ([(1S)-3-(benzyloxy)-1-[(2S)oxiranylmethyl]propyl]oxy)(tert-butyl)diphenylsilane 【CA登记号】 |
【 分 子 式 】C29H36O3Si 【 分 子 量 】460.68854 【元素组成】C 75.61% H 7.88% O 10.42% Si 6.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Synthesis of intermediate (VII): The condensation of epoxide (I) with vinyl lithium (II) by means of CuCN gives the allylic alcohol (III), which is epoxidated to epoxide (IV). The silylation of (IV) with TBDPSCl and imidazole yields the silyl ether (V), which is condensed with 1,3-dithiane (VI) by means of n-BuLi and protected with TBDPSCl as before to afford the desired intermediate (VII).
| 【1】 Guo, J.; et al.; Total synthesis of altohyrtin A (spongistatin 1): Part 1. Angew Chem. Int Ed Engl 1998, 37, 1-2, 187. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42367 | benzyl 2-[(2S)oxiranyl]ethyl ether; (2S)-2-[2-(benzyloxy)ethyl]oxirane | C11H14O2 | 详情 | 详情 | |
| (II) | 42368 | vinyllithium | 917-57-7 | C2H3Li | 详情 | 详情 |
| (III) | 42369 | (3R)-1-(benzyloxy)-5-hexen-3-ol | C13H18O2 | 详情 | 详情 | |
| (IV) | 42370 | (2S)-4-(benzyloxy)-1-[(2S)oxiranyl]-2-butanol | C13H18O3 | 详情 | 详情 | |
| (V) | 42371 | benzyl (3S)-3-[[tert-butyl(diphenyl)silyl]oxy]-4-[(2S)oxiranyl]butyl ether; ([(1S)-3-(benzyloxy)-1-[(2S)oxiranylmethyl]propyl]oxy)(tert-butyl)diphenylsilane | C29H36O3Si | 详情 | 详情 | |
| (VI) | 42372 | 1,3-dithiane | 505-23-7 | C4H8S2 | 详情 | 详情 |
| (VII) | 42373 | benzyl (3S,5S)-3,5-bis[[tert-butyl(diphenyl)silyl]oxy]-6-(1,3-dithian-2-yl)hexyl ether; (5S,7S)-5-[2-(benzyloxy)ethyl]-7-(1,3-dithian-2-ylmethyl)-2,2,10,10-tetramethyl-3,3,9,9-tetraphenyl-4,8-dioxa-3,9-disilaundecane | C49H62O3S2Si2 | 详情 | 详情 |
Extended Information