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【结 构 式】 
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【分子编号】42358 【品名】1-heptadecene 【CA登记号】6765-39-5 |
【 分 子 式 】C17H34 【 分 子 量 】238.45696 【元素组成】C 85.63% H 14.37% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)In a different procedure, treatment of olefin (VII) with N-bromosuccinimide produced bromohydrin (VIII), which was further oxidized to bromoketone (VI) by means of Jones reagent. Condensation of bromoketone (VI) with aminoalcohol (III) in nitromethane furnished the morpholine derivative (IX). The ester group was finally hydrolyzed with to yield the title compound.
| 【1】 Bryant, S.D.; Hubieki, M.P.; Robinette, R.G.; Gandourk, R.D.; Savle, P.S.; Doncel, G.F.; Acylcarnitine analogues as topical, microbicidal spermicides. Bioorg Med Chem Lett 1999, 9, 17, 2545. |
| 【2】 Gandour, R.D.; et al.; (+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransfease-I in intact mitochondria. J Med Chem 1993, 36, 2, 237. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 42355 | methyl (3R)-4-(dimethylamino)-3-hydroxybutanoate | C7H15NO3 | 详情 | 详情 | |
| (VI) | 42357 | 1-bromo-2-heptadecanone | C17H33BrO | 详情 | 详情 | |
| (VII) | 42358 | 1-heptadecene | 6765-39-5 | C17H34 | 详情 | 详情 |
| (VIII) | 42359 | 1-bromo-2-heptadecanol | C17H35BrO | 详情 | 详情 | |
| (IX) | 42360 | (2S,6R)-2-hydroxy-6-(2-methoxy-2-oxoethyl)-4,4-dimethyl-2-pentadecylmorpholin-4-ium bromide | C24H48BrNO4 | 详情 | 详情 |
Extended Information