【结 构 式】 |
【分子编号】42354 【品名】lithium (3R)-4-(dimethylamino)-3-hydroxybutanoate 【CA登记号】 |
【 分 子 式 】C6H12LiNO3 【 分 子 量 】153.10722 【元素组成】C 47.07% H 7.9% Li 4.53% N 9.15% O 31.35% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Intermediate hydroxyester (III) has been obtained as follows: Demethylation of (R)-carnitine (I) by thiophenol in dimethylaminoethanol, followed by precipitation with LiOH, gave lithium carboxylate (II), which was esterified to (III) by treatment either with H2SO4 in MeOH or with trimethyl orthoformate in refluxing methanol.
【1】 Bryant, S.D.; Hubieki, M.P.; Robinette, R.G.; Gandourk, R.D.; Savle, P.S.; Doncel, G.F.; Acylcarnitine analogues as topical, microbicidal spermicides. Bioorg Med Chem Lett 1999, 9, 17, 2545. |
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