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【结 构 式】

【分子编号】39210

【品名】(2S,3S,5S,8S,9S,10S,13S,14S,17S)-2-ethoxy-3-hydroxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)hexadecahydro-11H-cyclopenta[a]phenanthren-11-one

【CA登记号】

【 分 子 式 】C25H40O5

【 分 子 量 】420.5896

【元素组成】C 71.39% H 9.59% O 19.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The ketalization of 2beta-ethoxy-3alpha-hydroxy-5alpha-pregnane-11,20-dione (I) with ethylene glycol (A) by means of p-toluenesulfonic acid in refluxing benzene gives the corresponding 20,20-ethylenedioxy derivative (II), which is treated with hydroxylamine hydrochloride and NaOH refluxing ethanol to yield 20,20-ethylenedioxy-2beta-ethoxy-3alpha-hydroxy-5alpha-pregnan-11-one 11-oxime (III). The reduction of (III) with Na in refluxing propanol (B) affords 11alpha-amino-20,20-ethylenedioxy-2beta-ethoxy-3alpha-hydroxy-5alpha-pregnan (IV), which is finally methylated with methyl iodide and K2CO3 or with formaldehyde and formic acid, and hydrolyzed with HCl or H2SO4.

1 Philips, G.H.; Ewan, G.; DE 2715078 .
2 Hillier, K.; Castaner, J.; Blancafort, P.; Serradell, M.N.; Minaxolone. Drugs Fut 1980, 5, 12, 614.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(AI) 11295 Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol 107-21-1 C2H6O2 详情 详情
(B) 29338 1-propanol 71-23-8 C3H8O 详情 详情
(I) 39209 (2S,3S,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-2-ethoxy-3-hydroxy-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one C23H36O4 详情 详情
(II) 39210 (2S,3S,5S,8S,9S,10S,13S,14S,17S)-2-ethoxy-3-hydroxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)hexadecahydro-11H-cyclopenta[a]phenanthren-11-one C25H40O5 详情 详情
(III) 39211 (2S,3S,5S,8S,9S,10S,13S,14S,17S)-2-ethoxy-3-hydroxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)hexadecahydro-11H-cyclopenta[a]phenanthren-11-one oxime C25H41NO5 详情 详情
(IV) 39212 (2S,3S,5S,8S,9S,10S,11R,13S,14S,17S)-11-amino-2-ethoxy-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol C25H43NO4 详情 详情
Extended Information