2,6-dichloro-4,8-di(1-piperidinyl)pyrimido[5,4-d]pyrimidine -Drug Synthesis Database

【结构式】

【分子编号】39202

【品名】2,6-dichloro-4,8-di(1-piperidinyl)pyrimido[5,4-d]pyrimidine

【CA登记号】

【分子式】C₁₆H₂₀Cl₂N₆

【分子量】367.28064

【元素组成】C 52.32% H 5.49% Cl 19.31% N 22.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine (I) with piperidine (A) at room temperature gives 2,6-dichloro-4,8-di(N-piperidino)pyrimido[5,4-d]pyrimidine (II), which is treated with diethanolamine (B) at 200 C to yield 2,6-bis(diethanolamino)-4,8-di(N-piperidino)pyrimido[5,4-d])pyrimidine (III) (1). The reduction of (III) with Zn in hot formic or acetic acid or in hot aqueous HCl gives 2,6-bis(diethanolamino)-8-(N-piperidino)-1,2,3,4-tetrahydropyrimido[5,4-d]pyrimidine (IV), which is then dehydrogenated with I2 - KI in water.

参考文献中间体

合成目标

【1】 Castañer, J.; Serradell, M.N.; Blancafort, P.; Owen, R.T.; Mopidamol. Drugs Fut 1980, 5, 11, 550.
【2】 US 3322755 .
【3】 Fischer, F.G.; et al.; US 3031450 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	10158	Piperidine	110-89-4	C₅H₁₁N	详情	详情
(B)	24273	2-[(2-hydroxyethyl)amino]-1-ethanol	111-42-2	C₄H₁₁NO₂	详情	详情
(I)	36173	2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine		C₆Cl₄N₄	详情	详情
(II)	39202	2,6-dichloro-4,8-di(1-piperidinyl)pyrimido[5,4-d]pyrimidine		C₁₆H₂₀Cl₂N₆	详情	详情
(III)	39203	2-[[6-[bis(2-hydroxyethyl)amino]-4,8-di(1-piperidinyl)pyrimido[5,4-d]pyrimidin-2-yl](2-hydroxyethyl)amino]-1-ethanol	58-32-2	C₂₄H₄₀N₈O₄	详情	详情
(IV)	39204	2-[[6-[bis(2-hydroxyethyl)amino]-4-(1-piperidinyl)-5,6,7,8-tetrahydropyrimido[5,4-d]pyrimidin-2-yl](2-hydroxyethyl)amino]-1-ethanol		C₁₉H₃₅N₇O₄	详情	详情

Extended Information