4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-oic acid -Drug Synthesis Database

【结构式】

【分子编号】38284

【品名】4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-oic acid

【CA登记号】

【分子式】C₂₆H₂₈N₄O₃S

【分子量】476.59948

【元素组成】C 65.52% H 5.92% N 11.76% O 10.07% S 6.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The condensation of 5-amino-1,3,4-thiadiazol-2-sulfonamide (I) with the protected guanidinodipeptide (II) by means of EDC in acetonitrile gives the corresponding amide (III), which is then deprotected with HCl in hot dioxane.

参考文献中间体

合成目标

【1】 Mincione, F.; Briganti, F.; Mincione, G.; Scozzafava, A.; Menabuoni, L.; Supuran, C.T.; Carbonic anhydrase inhibitors: Synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. J Med Chem 1999, 42, 18, 3690.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	38281	5-amino-1,3,4-thiadiazole-2-sulfonamide	C₂H₄N₄O₂S₂	详情	详情
(II)	38284	4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-oic acid	C₂₆H₂₈N₄O₃S	详情	详情
(III)	38285	N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-amide	C₂₈H₃₀N₈O₄S₃	详情	详情

Extended Information