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【结 构 式】

【分子编号】38284

【品名】4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-oic acid

【CA登记号】

【 分 子 式 】C26H28N4O3S

【 分 子 量 】476.59948

【元素组成】C 65.52% H 5.92% N 11.76% O 10.07% S 6.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The condensation of 5-amino-1,3,4-thiadiazol-2-sulfonamide (I) with the protected guanidinodipeptide (II) by means of EDC in acetonitrile gives the corresponding amide (III), which is then deprotected with HCl in hot dioxane.

1 Mincione, F.; Briganti, F.; Mincione, G.; Scozzafava, A.; Menabuoni, L.; Supuran, C.T.; Carbonic anhydrase inhibitors: Synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. J Med Chem 1999, 42, 18, 3690.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 38281 5-amino-1,3,4-thiadiazole-2-sulfonamide C2H4N4O2S2 详情 详情
(II) 38284 4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-oic acid C26H28N4O3S 详情 详情
(III) 38285 N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-4-imino-5-methyl-7-oxo-1,1,1-triphenyl-2-thia-3,5,8-triazaundecan-11-amide C28H30N8O4S3 详情 详情
Extended Information