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【结 构 式】 
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【分子编号】38165 【品名】ethyl 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylate 【CA登记号】 |
【 分 子 式 】C12H14N2O4S 【 分 子 量 】282.32024 【元素组成】C 51.05% H 5% N 9.92% O 22.67% S 11.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Ethyl 5-nitroindole-2-carboxylate (I) was hydrogenated over Pd/C to give amino indole (II), which was condensed with methanesulfonyl chloride, affording sulfonamide (III). Subsequent hydrolysis of the ester group of (III) furnished the intermediate indolecarboxylic acid (IV).
| 【1】 Romero, D.L.; Thomas, R.C.; May, P.D.; Poel, T.-J. (Pharmacia Corp.); Alkyl substd. piperadinyl and piperazinyl anti-AIDS cpds.. EP 0797576; JP 1998510530; US 5866589; WO 9618628 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 38163 | ethyl 5-nitro-1H-indole-2-carboxylate | 16732-57-3 | C11H10N2O4 | 详情 | 详情 |
| (II) | 38164 | ethyl 5-amino-1H-indole-2-carboxylate | C11H12N2O2 | 详情 | 详情 | |
| (III) | 38165 | ethyl 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylate | C12H14N2O4S | 详情 | 详情 | |
| (IV) | 38166 | 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid | C10H10N2O4S | 详情 | 详情 |
Extended Information