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【结 构 式】 
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【分子编号】38153 【品名】3-methyl-2-thioxo-1,3-thiazolidin-4-one 【CA登记号】 |
【 分 子 式 】C4H5NOS2 【 分 子 量 】147.22184 【元素组成】C 32.63% H 3.42% N 9.51% O 10.87% S 43.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Alkylation of 2-hydroxy-1-naphthaldehyde (I) with ethyl 4-bromobutyrate (II) in the presence of K2CO3 and tris[2-(2-methoxyethoxy)ethyl]amine furnished the naph-thoxybutyrate ester (III), which was hydrolyzed to the corresponding carboxylic acid (IV) using NaOH in aqueous dioxan. Condensation of (IV) with N-methyl rhodanine (V) by means of NaOAc in refluxing AcOH gave rise to the title compound.
| 【1】 Fujitani, B.; Mizuta, H.; Murata, M.; Synthesis and aldose reductase inhibitory activity of a new series of 5-[[2-(omega-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Eur J Med Chem 1999, 34, 12, 1061. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 38150 | 2-hydroxy-1-naphthaldehyde | 708-06-5 | C11H8O2 | 详情 | 详情 |
| (II) | 11263 | ethyl 4-bromobutanoate; Ethyl 4-bromobutyrate | 2969-81-5 | C6H11BrO2 | 详情 | 详情 |
| (III) | 38151 | ethyl 4-[(1-formyl-2-naphthyl)oxy]butanoate | C17H18O4 | 详情 | 详情 | |
| (IV) | 38152 | 4-[(1-formyl-2-naphthyl)oxy]butyric acid | C15H14O4 | 详情 | 详情 | |
| (V) | 38153 | 3-methyl-2-thioxo-1,3-thiazolidin-4-one | C4H5NOS2 | 详情 | 详情 |
Extended Information