|
【结 构 式】 
|
【分子编号】38135 【品名】N-[(3R)-1-[amino(imino)methyl]-2-ethoxypiperidinyl]-2-[(3S)-3-[(benzylsulfonyl)amino]-7-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetamide 【CA登记号】 |
【 分 子 式 】C28H38N6O6S 【 分 子 量 】586.71256 【元素组成】C 57.32% H 6.53% N 14.32% O 16.36% S 5.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XV)Hydrogenolysis of the nitro group from the guanidine (XIV) provided (XV). Then, mild acid hydrolysis of the ethyl acetal of (XV) furnished the title compound, which was finally isolated as the corresponding trifluoroacetate salt.
| 【1】 Tamura, S.Y.; Goldman, E.A.; Semple, J.E.; Bergum, P.W.; Novel benzo-fused lactam scaffolds as factor Xa inhibitors. Bioorg Med Chem Lett 1999, 9, 17, 2573. |
Extended Information