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【结 构 式】 
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【分子编号】38106 【品名】2,2-dimethoxy-1-ethanol 【CA登记号】30934-97-5 |
【 分 子 式 】C4H10O3 【 分 子 量 】106.1216 【元素组成】C 45.27% H 9.5% O 45.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXI)Malonic acid allyl, 2,2-dimethoxyethyl diester (scheme 13922101a, cp. (II)). The reaction of allyl acetate (XXIX) with LDA and CO2 in ethyl ether gives the malonic acid monoallyl ester (XXX), which is then esterified with 2,2-dimethoxyethanol (XXXI) by means of BOP-Cl and TEA in dichloromethane to afford the desired intermediate (II).
| 【1】 Gin, D.Y.; Corey, E.J.; Kania, R.S.; Enantioselective total synthesis of Ecteinascidin 743. J Am Chem Soc 1996, 118, 38, 9202-03. |
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