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【结 构 式】 
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【分子编号】38100 【品名】methyl (2S)-3-dibenzo[b,d]furan-3-yl-2-[[(diphenoxyphosphoryl)methyl]amino]propanoate 【CA登记号】 |
【 分 子 式 】C29H26NO6P 【 分 子 量 】515.502342 【元素组成】C 67.57% H 5.08% N 2.72% O 18.62% P 6.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Acid hydrolysis of the acetamido group of (V) gave amino acid (XI), which was further esterified with HCl in MeOH yielding ester (XII). Condensation of amino ester (XII) with formaldehyde, followed by reaction of the intermediate trimeric hexahydrotriazine with diphenyl phosphite furnished alpha-aminophosphonate (XIII). Finally, acid hydrolysis of carboxylate and phosphonate ester groups of (XIII) gave rise to the title compound.
| 【1】 Blanchard, L.; De Lombaert, S.; Stamford, L.B.; et al.; Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J Med Chem 2000, 43, 3, 488. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 38084 | (2S)-2-(acetamido)-3-dibenzo[b,d]furan-3-ylpropionic acid | C17H15NO4 | 详情 | 详情 | |
| (XI) | 38090 | (2S)-2-amino-3-dibenzo[b,d]furan-3-ylpropionic acid | C15H13NO3 | 详情 | 详情 | |
| (XII) | 38091 | methyl (2S)-2-amino-3-dibenzo[b,d]furan-3-ylpropanoate | C16H15NO3 | 详情 | 详情 | |
| (XIII) | 38100 | methyl (2S)-3-dibenzo[b,d]furan-3-yl-2-[[(diphenoxyphosphoryl)methyl]amino]propanoate | C29H26NO6P | 详情 | 详情 |
Extended Information