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【结 构 式】 
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【分子编号】38024 【品名】2-diazo-1-(2-naphthyl)-1-ethanone 【CA登记号】 |
【 分 子 式 】C12H8N2O 【 分 子 量 】196.2084 【元素组成】C 73.46% H 4.11% N 14.28% O 8.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of the 32-OH of ascomycin (I) with the diazoketone (II) by means of a Rh catalyst gives the addition product (III), which is silylated at the 24-OH with TES-Cl yielding the silyl ether (IV). The reduction of the new carbonyl group of (IV) with the chiral reducing agent (S)-OAB/BH3 and TEA affords the silylated target compound (V), which is finally treated with HCl to eliminate the TES- group.
| 【1】 Nelson, T.D.; et al.; Rhodium-carbenoid-mediated intermolecular O-H insertion reactions: A dramatic additive effect. Application in the synthesis of an ascomycin derivative. Tetrahedron Lett 2000, 41, 12, 1877. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14951 | (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18-ene-2,3,10,16-tetron | C43H69NO12 | 详情 | 详情 | |
| (II) | 38024 | 2-diazo-1-(2-naphthyl)-1-ethanone | C12H8N2O | 详情 | 详情 | |
| (III) | 38025 | C55H77NO13 | 详情 | 详情 | ||
| (IV) | 38026 | C61H91NO13Si | 详情 | 详情 | ||
| (V) | 38027 | C61H93NO13Si | 详情 | 详情 |
Extended Information