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【结 构 式】 
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【分子编号】37981 【品名】(6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[[(trifluoromethyl)sulfonyl]oxy]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 【CA登记号】 |
【 分 子 式 】C16H13F3N2O7S2 【 分 子 量 】466.4157096 【元素组成】C 41.2% H 2.81% F 12.22% N 6.01% O 24.01% S 13.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)In an alternative method, benzhydryl ester (V) was cleaved with trifluoroacetic acid to give carboxylic acid (VI). After protection of (VI) by means of trimethylsilyl acetamide, the triflate group was displaced by the potassium salt of mercapto thiadiazole (III) to furnish the title compound.
| 【1】 Tawara, S.; Sasaki, H.; Matsumoto, S.; Takasugi, H.; Yoshida, Y.; Matsumoto, Y.; Matsuda, K.; Studies of anti-Helicobacter pylori agents. Part 2: New cephem derivatives. Bioorg Med Chem 2000, 8, 9, 2317. |
| 【2】 Yoshida, Y.; Okuda, S.; Sasaki, H.; Matsuda, K.; Takasugi, H. (Fujisawa Pharmaceutical Co., Ltd.); New cephem cpds. and pharmaceutical use thereof. EP 0882052; JP 2000505432; WO 9729111 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 37978 | 5-methyl-1,3,4-thiadiazole-2-thiol; 5-methyl-1,3,4-thiadiazol-2-ylhydrosulfide | 29490-19-5 | C3H4N2S2 | 详情 | 详情 |
| (V) | 37980 | benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[[(trifluoromethyl)sulfonyl]oxy]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C29H23F3N2O7S2 | 详情 | 详情 | |
| (VI) | 37981 | (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[[(trifluoromethyl)sulfonyl]oxy]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C16H13F3N2O7S2 | 详情 | 详情 | |
| (VII) | 37982 | trimethylsilyl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[[(trifluoromethyl)sulfonyl]oxy]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C19H21F3N2O7S2Si | 详情 | 详情 |
Extended Information