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【结 构 式】 
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【分子编号】37911 【品名】N-cyclopropyl-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide 【CA登记号】 |
【 分 子 式 】C21H20N4O5 【 分 子 量 】408.41376 【元素组成】C 61.76% H 4.94% N 13.72% O 19.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The known 7,8-dihydro-8-methyl-5-(4-nitrophenyl)-9H-1,3-dioxolo-[4,5-h]-2,3-benzodiazepine (I) was condensed with 1,1'-carbonyldiimidazole (II) in refluxing THF to produce imidazolide (III). Subsequent reaction of (III) with boiling cyclopropylamine (IV) gave rise to the cyclopropylcarbamoyl derivative (V). The nitro group of (V) was then reduced to the corresponding amine by hydrogenation over Pd/C.
| 【1】 1,3-Dioxolo[4,5-h][2,3]benzodiazepine derivs. as AMPA/kainate receptor inhibitors. EP 1015457; WO 9907708 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37909 | 8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine | C17H15N3O4 | 详情 | 详情 | |
| (II) | 11353 | 1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole) | 530-62-1 | C7H6N4O | 详情 | 详情 |
| (III) | 37910 | 1H-imidazol-1-yl[8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]methanone | C21H17N5O5 | 详情 | 详情 | |
| (IV) | 12263 | Cyclopropylamine; Cyclopropanamine | 765-30-0 | C3H7N | 详情 | 详情 |
| (V) | 37911 | N-cyclopropyl-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide | C21H20N4O5 | 详情 | 详情 |
Extended Information