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【结 构 式】 
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【分子编号】37735 【品名】(isobutyryloxy)methyl (4R,5R,6S)-6-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-3-[(diphenoxyphosphoryl)oxy]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 【CA登记号】 |
【 分 子 式 】C33H44NO10PSi 【 分 子 量 】673.772362 【元素组成】C 58.83% H 6.58% N 2.08% O 23.75% P 4.6% Si 4.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXI)Ring contraction of (XXIX) by desulfurizing treatment with triphenylphosphine produced oxocarbapenam (XXX). This was converted to vinyl phosphate (XXXI) and then condensed with mercapto pyrrolidinethione (IV) to give thioether (XXXII). Desilylation of (XXXII) to produce the title compound was carried out by treatment with a variety of fluoride reagents including KF, NH4F·HF and CaF2.
| 【1】 Horikawa, H.; Iwasaki, T.; Kondo, K. (Tanabe Seiyaku Co., Ltd.); Method for removing the protecting group for hydroxy group. EP 0567949 . |
| 【2】 Horikawa, H.; Iwasaki, T.; Kondo, K. (Tanabe Seiyaku Co., Ltd.); Process for preparing beta-lactam deriv. and synthetic intermediate thereof. EP 0559533 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 37712 | (4R)-4-sulfanyl-2-pyrrolidinethione | C4H7NS2 | 详情 | 详情 | |
| (XXIX) | 37733 | (isobutyryloxy)methyl (5R,6S,7S)-7-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-5-methyl-4,8-dioxo-3-thia-1-azabicyclo[4.2.0]octane-2-carboxylate | C21H35NO7SSi | 详情 | 详情 | |
| (XXX) | 37734 | (isobutyryloxy)methyl (4R,5R,6S)-6-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate | C21H35NO7Si | 详情 | 详情 | |
| (XXXI) | 37735 | (isobutyryloxy)methyl (4R,5R,6S)-6-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-3-[(diphenoxyphosphoryl)oxy]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C33H44NO10PSi | 详情 | 详情 | |
| (XXXII) | 37736 | (isobutyryloxy)methyl (4R,5S,6S)-6-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-4-methyl-7-oxo-3-[[(3R)-5-thioxopyrrolidinyl]sulfanyl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C25H40N2O6S2Si | 详情 | 详情 |
Extended Information