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【结 构 式】 
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【分子编号】37711 【品名】S-[(3R)-5-thioxopyrrolidinyl] ethanethioate 【CA登记号】 |
【 分 子 式 】C6H9NOS2 【 分 子 量 】175.2756 【元素组成】C 41.12% H 5.18% N 7.99% O 9.13% S 36.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The original procedure for the synthesis of the intermediate (R)-4-mercaptopyrrolidine-2-thione (IV) started from (S)-4-hydroxy-2-pyrrolidinone (I). Mitsunobu coupling with thioacetic acid produced the (R)-thioacetate ester (II). Conversion of (II) to the thiolactam (III) was achieved by treatment with Lawesson's reagent. The thioester group of (III) was then hydrolyzed by means of methanolic ammonia.
| 【1】 Iwasaki, T.; Kondo, K.; Horikawa, H.; Yamaguchi, T.; Matsushita, T. (Tanabe Seiyaku Co., Ltd.); 1-Methylcarbapenem derivs. and process for preparation thereof. EP 0474243; JP 1992279588; US 5153187 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17188 | (S)-4-hydroxy-2-pyrrolidone; (4S)-4-hydroxytetrahydro-2H-pyrrol-2-one; (S)-4-hydroxypyrrolidone | 68108-18-9 | C4H7NO2 | 详情 | 详情 |
| (II) | 17191 | S-[(3R)-5-oxotetrahydro-1H-pyrrol-3-yl] ethanethioate | C6H9NO2S | 详情 | 详情 | |
| (III) | 37711 | S-[(3R)-5-thioxopyrrolidinyl] ethanethioate | C6H9NOS2 | 详情 | 详情 | |
| (IV) | 37712 | (4R)-4-sulfanyl-2-pyrrolidinethione | C4H7NS2 | 详情 | 详情 |
Extended Information