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【结 构 式】 
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【分子编号】37561 【品名】(1S,2R,3aS,6aS)-1-[(E,3S)-3-(acetoxy)-1-octenyl]-5-[(E)-6-(tetrahydro-2H-pyran-2-yloxy)hexylidene]octahydro-2-pentalenyl acetate 【CA登记号】 |
【 分 子 式 】C31H50O6 【 分 子 量 】518.7344 【元素组成】C 71.78% H 9.72% O 18.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LXV)Selective hydrolysis of the silyl groups of (LXIV), and acetylation with acetic anhydride yields the diacetate (LXV), which is hydrolyzed again selectively with acetic acid, and oxidized with Jones reagent to afford the carbacyclin diacetate (LXVI) Finally, this compound is hydrolyzed with base.
| 【1】 Morton, D.R.Jr.; DE 2904655 . |
| 【2】 Brokaw, F.C.; Morton, D.R.Jr.; Total synthesis of 6a-carboprostaglandin I2 and related isomers. J Org Chem 1979, 44, 16, 2880-87. |
| 【3】 Castaner, J.; Hillier, K.; Carbacyclin. Drugs Fut 1981, 6, 12, 753. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (LXIV) | 37560 | [((1S,2E)-3-[(1S,2R,3aS,6aS)-2-[[tert-butyl(dimethyl)silyl]oxy]-5-[(E)-6-(tetrahydro-2H-pyran-2-yloxy)hexylidene]octahydro-1-pentalenyl]-1-pentyl-2-propenyl)oxy](tert-butyl)dimethylsilane; 6-[(3aS,4S,5R,6aS)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-((E,3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-1-octenyl)hexahydro-2(1H)-pentalenylidene]hexyl tetrahydro-2H-pyran-2-yl ether | C39H74O4Si2 | 详情 | 详情 | |
| (LXV) | 37561 | (1S,2R,3aS,6aS)-1-[(E,3S)-3-(acetoxy)-1-octenyl]-5-[(E)-6-(tetrahydro-2H-pyran-2-yloxy)hexylidene]octahydro-2-pentalenyl acetate | C31H50O6 | 详情 | 详情 | |
| (LXVI) | 37562 | 5-[(3aS,4S,5R,6aS)-5-(acetoxy)-4-[(E,3S)-3-(acetoxy)-1-octenyl]hexahydro-2(1H)-pentalenylidene]pentanoic acid | C25H38O6 | 详情 | 详情 |
Extended Information