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【结 构 式】 
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【分子编号】37408 【品名】5-oxo-2,5-dihydro-2-furanyl methylcarbamate 【CA登记号】 |
【 分 子 式 】C6H7NO4 【 分 子 量 】157.12592 【元素组成】C 45.87% H 4.49% N 8.91% O 40.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)This compound can be obtained in two different ways: 1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF. 2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.
| 【1】 Wiersdorff, W.W.; Wilsmann, K.; DE 2510714 . |
| 【2】 Ammann, A.; et al. (BASF AG); Carbamates and their use as pharmaceuticals. US 3965119 . |
| 【3】 Blancafort, P.; Neuman, M.; Serradell, M.N.; Castaner, J.; LU-253. Drugs Fut 1981, 6, 2, 89. |
Extended Information