【结 构 式】 |
【分子编号】37391 【品名】(2R)-1-(2,6-dimethylphenoxy)-2-propanol 【CA登记号】 |
【 分 子 式 】C11H16O2 【 分 子 量 】180.24684 【元素组成】C 73.3% H 8.95% O 17.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The addition reaction of 2,6-dimethylphenol (II) to (R)-2-methyloxirane (I) by means of NaOH in acetonitrile gives (R)-1-(2,6-dimethylphenoxy)-2-propanol (III), which is condensed with phthalimide (IV) by means of DEAD and PPh3 (with inversion of configuration) yielding N-[2-(2,6-dimethylphenoxy)-1(S)-methylethyl]phthalimide (V). Finally, this compound is treated with hydrazine and acetic acid in methanol to eliminate the phthalimido group.
【1】 Carocci, A.; et al.; Facile entry to (-)-(R)- and (+)-(S)-mexiletine. Chirality 2000, 12, 3, 103. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 29268 | (2S)-2-methyloxirane | 16088-62-3 | C3H6O | 详情 | 详情 |
(II) | 37388 | 2,6-dimethylphenol | 576-26-1 | C8H10O | 详情 | 详情 |
(III) | 37391 | (2R)-1-(2,6-dimethylphenoxy)-2-propanol | C11H16O2 | 详情 | 详情 | |
(IV) | 12376 | Phthalimide; 1H-Isoindole-1,3(2H)-dione; Isoindole-1,3-dione;Phthalic dicarboximide;Phenylimide;Isoindole-1,3-dione | 85-41-6 | C8H5NO2 | 详情 | 详情 |
(V) | 37392 | 2-[(1S)-2-(2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione | C19H19NO3 | 详情 | 详情 |
Extended Information