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【结 构 式】

【分子编号】37341

【品名】5-[(tert-butoxycarbonyl)amino]pentanoic acid

【CA登记号】

【 分 子 式 】C10H19NO4

【 分 子 量 】217.2652

【元素组成】C 55.28% H 8.81% N 6.45% O 29.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XX)

Then, two sequential couplings with N-Boc-5-aminopentanoic acid (XX), followed by deprotections with trifluoroacetic acid in the presence of ethyl methyl sulfide, provided peptide resins (XXI) and (XXII).

1 DiMaio, J. (National Research Council of Canada); Thrombin inhibitors based on the amino acid sequence of hirudin. JP 1999502203; WO 9629347 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIX) 37340 (2S)-2-[[((2S)-1-[(2S,3S)-2-[([(2S)-1-[(2S)-2-[((2S)-2-[[(2S)-2-amino-4-(cyclohexyloxy)-4-oxobutanoyl]amino]-3-phenylpropanoyl)amino]-5-(benzyloxy)-5-oxopentanoyl]pyrrolidinyl]carbonyl)amino]-3-methylpentanoyl]pyrrolidinyl)carbonyl]amino]-4-methylpentanoic acid C53H75N7O12 详情 详情
(XX) 37341 5-[(tert-butoxycarbonyl)amino]pentanoic acid C10H19NO4 详情 详情
(XXI) 37342 (2S)-2-[[((2S)-1-[(2S,3S)-2-[([(2S)-1-[(2S)-2-[((2S)-2-[[(2S)-2-[(5-aminopentanoyl)amino]-4-(cyclohexyloxy)-4-oxobutanoyl]amino]-3-phenylpropanoyl)amino]-5-(benzyloxy)-5-oxopentanoyl]pyrrolidinyl]carbonyl)amino]-3-methylpentanoyl]pyrrolidinyl)carbonyl]amino]-4-methylpentanoic acid C58H84N8O13 详情 详情
(XXII) 37343 (2S)-2-([[(2S)-1-((2S,3S)-2-[[((2S)-1-[(2S,5S,8S)-20-amino-5-benzyl-2-[3-(benzyloxy)-3-oxopropyl]-8-[2-(cyclohexyloxy)-2-oxoethyl]-4,7,10,16-tetraoxo-3,6,9,15-tetraazaicos-1-anoyl]pyrrolidinyl)carbonyl]amino]-3-methylpentanoyl)pyrrolidinyl]carbonyl]amino)-4-methylpentanoic acid C63H93N9O14 详情 详情
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