5-[(tert-butoxycarbonyl)amino]pentanoic acid -Drug Synthesis Database

【结构式】

【分子编号】37341

【品名】5-[(tert-butoxycarbonyl)amino]pentanoic acid

【CA登记号】

【分子式】C₁₀H₁₉NO₄

【分子量】217.2652

【元素组成】C 55.28% H 8.81% N 6.45% O 29.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XX)

Then, two sequential couplings with N-Boc-5-aminopentanoic acid (XX), followed by deprotections with trifluoroacetic acid in the presence of ethyl methyl sulfide, provided peptide resins (XXI) and (XXII).

参考文献中间体

合成目标

【1】 DiMaio, J. (National Research Council of Canada); Thrombin inhibitors based on the amino acid sequence of hirudin. JP 1999502203; WO 9629347 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XIX)	37340	(2S)-2-[[((2S)-1-[(2S,3S)-2-[([(2S)-1-[(2S)-2-[((2S)-2-[[(2S)-2-amino-4-(cyclohexyloxy)-4-oxobutanoyl]amino]-3-phenylpropanoyl)amino]-5-(benzyloxy)-5-oxopentanoyl]pyrrolidinyl]carbonyl)amino]-3-methylpentanoyl]pyrrolidinyl)carbonyl]amino]-4-methylpentanoic acid	C₅₃H₇₅N₇O₁₂	详情	详情
(XX)	37341	5-[(tert-butoxycarbonyl)amino]pentanoic acid	C₁₀H₁₉NO₄	详情	详情
(XXI)	37342	(2S)-2-[[((2S)-1-[(2S,3S)-2-[([(2S)-1-[(2S)-2-[((2S)-2-[[(2S)-2-[(5-aminopentanoyl)amino]-4-(cyclohexyloxy)-4-oxobutanoyl]amino]-3-phenylpropanoyl)amino]-5-(benzyloxy)-5-oxopentanoyl]pyrrolidinyl]carbonyl)amino]-3-methylpentanoyl]pyrrolidinyl)carbonyl]amino]-4-methylpentanoic acid	C₅₈H₈₄N₈O₁₃	详情	详情
(XXII)	37343	(2S)-2-([[(2S)-1-((2S,3S)-2-[[((2S)-1-[(2S,5S,8S)-20-amino-5-benzyl-2-[3-(benzyloxy)-3-oxopropyl]-8-[2-(cyclohexyloxy)-2-oxoethyl]-4,7,10,16-tetraoxo-3,6,9,15-tetraazaicos-1-anoyl]pyrrolidinyl)carbonyl]amino]-3-methylpentanoyl)pyrrolidinyl]carbonyl]amino)-4-methylpentanoic acid	C₆₃H₉₃N₉O₁₄	详情	详情

Extended Information