【结 构 式】 |
【分子编号】37331 【品名】bromo(5-hexenyl)magnesium 【CA登记号】 |
【 分 子 式 】C6H11BrMg 【 分 子 量 】187.36234 【元素组成】C 38.46% H 5.92% Br 42.65% Mg 12.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Nalpha-Boc-Ngamma-tosyl-L-arginine (I) was converted to the N,O-dimethyl hydroxamate (II) by treatment with dimethylhydroxylamine and BOP. Condensation of (II) with the Grignard reagent (IV), prepared from 6-bromo-1-hexene (III), produced ketone (V). Then, oxidative cleavage of the terminal alkene of (V) by means of NaIO4 and RuCl3 yielded carboxylic acid (VI).
【1】 DiMaio, J. (National Research Council of Canada); Thrombin inhibitors based on the amino acid sequence of hirudin. JP 1999502203; WO 9629347 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 | |
(I) | 19064 | (2S)-2-[(tert-butoxycarbonyl)amino]-5-[(imino[[(4-methylphenyl)sulfonyl]amino]methyl)amino]pentanoic acid | C18H28N4O6S | 详情 | 详情 | |
(II) | 37329 | tert-butyl (1S)-4-[(imino[[(4-methylphenyl)sulfonyl]amino]methyl)amino]-1-[[methoxy(methyl)amino]carbonyl]butylcarbamate | C20H33N5O6S | 详情 | 详情 | |
(III) | 37330 | 6-bromo-1-hexene | 2695-47-8 | C6H11Br | 详情 | 详情 |
(IV) | 37331 | bromo(5-hexenyl)magnesium | C6H11BrMg | 详情 | 详情 | |
(V) | 37332 | tert-butyl (1S)-1-[3-[(imino[[(4-methylphenyl)sulfonyl]amino]methyl)amino]propyl]-2-oxo-7-octenylcarbamate | C24H38N4O5S | 详情 | 详情 | |
(VI) | 37333 | (7S)-7-[(tert-butoxycarbonyl)amino]-10-[(imino[[(4-methylphenyl)sulfonyl]amino]methyl)amino]-6-oxodecanoic acid | C23H36N4O7S | 详情 | 详情 |
Extended Information