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【结 构 式】 
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【分子编号】37328 【品名】 【CA登记号】 |
【 分 子 式 】C50H64IN2Na13O66S11 【 分 子 量 】2527.529494 【元素组成】C 23.76% H 2.55% I 5.02% N 1.11% Na 11.82% O 41.78% S 13.96% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(XV)Amine (XIII) was coupled with the 4-(iodoacetamido)benzoic acid active ester (XIV) to produce amide (XV).
| 【1】 Buijsman, R.C.; van Boeckel, C.A.A.; van der Marel, G.A.; Basten, J.E.M.; van Dinther, T.G.; van Boom, J.H.; Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action. Bioorg Med Chem Lett 1999, 9, 14, 2013. |
| 【2】 Van Boeckel, C.A.A.; Basten, J.E.M.; Dreef-Tromp, C.M.; Buijsman, R.C. (Akzo Nobel N.V.; Universiteit Leiden); Antithrombotic cpds.. WO 9965934 . |
合成路线2
该中间体在本合成路线中的序号：(XV)Displacement of the iodide of (XV) by thiol (VIII) gave rise to the title sulfide derivative.
| 【1】 Buijsman, R.C.; van Boeckel, C.A.A.; van der Marel, G.A.; Basten, J.E.M.; van Dinther, T.G.; van Boom, J.H.; Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action. Bioorg Med Chem Lett 1999, 9, 14, 2013. |
| 【2】 Van Boeckel, C.A.A.; Basten, J.E.M.; Dreef-Tromp, C.M.; Buijsman, R.C. (Akzo Nobel N.V.; Universiteit Leiden); Antithrombotic cpds.. WO 9965934 . |
Extended Information