【结 构 式】 |
【分子编号】37324 【品名】 【CA登记号】 |
【 分 子 式 】C49H77NO33 【 分 子 量 】1208.13732 【元素组成】C 48.71% H 6.42% N 1.16% O 43.7% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XI)The known pentasaccharide (IX) was reacted with N-(benzyloxycarbonyl)succinimide (X) yielding carbamate (XI). Sulfation of the free hydroxyl groups of (XI) with triethylamine-sulfur trioxide complex gave the sulfated compound which, after acid cleavage of the formed N-SO3- groups, was converted to the corresponding sodium salt (XII). Hydrogenolysis of the N-benzyloxycarbonyl group then liberated amine (XIII).
【1】 Buijsman, R.C.; van Boeckel, C.A.A.; van der Marel, G.A.; Basten, J.E.M.; van Dinther, T.G.; van Boom, J.H.; Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action. Bioorg Med Chem Lett 1999, 9, 14, 2013. |
【2】 Van Boeckel, C.A.A.; Basten, J.E.M.; Dreef-Tromp, C.M.; Buijsman, R.C. (Akzo Nobel N.V.; Universiteit Leiden); Antithrombotic cpds.. WO 9965934 . |
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